Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase

Sida Shen; Arseniy Butrin; Peter F. Doubleday; Rafael D. Melani; Brett A. Beaupre; Mauricio T. Tavares; Glaucio M. Ferreira; Neil L. Kelleher; Graham R. Moran; Dali Liu; Richard B. Silverman

doi:10.1021/jacs.1c02456

Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase

Sida Shen
, Arseniy Butrin
, Peter F. Doubleday
, Rafael D. Melani
, Brett A. Beaupre
, Mauricio T. Tavares
, Glaucio M. Ferreira
, Neil L. Kelleher
, Graham R. Moran
, Dali Liu
, Richard B. Silverman

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	8689-8703
Number of pages	15
Journal	Chemistry Faculty Research and Publications
Volume	143
Issue number	23
DOIs	https://doi.org/10.1021/jacs.1c02456
State	Published - Jun 16 2021
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/jacs.1c02456

Cite this

Shen, S., Butrin, A., Doubleday, P. F., Melani, R. D., Beaupre, B. A., Tavares, M. T., Ferreira, G. M., Kelleher, N. L., Moran, G. R., Liu, D., & Silverman, R. B. (2021). Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase. Chemistry Faculty Research and Publications, 143(23), 8689-8703. https://doi.org/10.1021/jacs.1c02456

Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase. / Shen, Sida; Butrin, Arseniy; Doubleday, Peter F. et al.
In: Chemistry Faculty Research and Publications, Vol. 143, No. 23, 16.06.2021, p. 8689-8703.

Research output: Contribution to journal › Article › peer-review

Shen, S, Butrin, A, Doubleday, PF, Melani, RD, Beaupre, BA, Tavares, MT, Ferreira, GM, Kelleher, NL, Moran, GR , Liu, D & Silverman, RB 2021, 'Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase', Chemistry Faculty Research and Publications, vol. 143, no. 23, pp. 8689-8703. https://doi.org/10.1021/jacs.1c02456

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author = "Sida Shen and Arseniy Butrin and Doubleday, \{Peter F.\} and Melani, \{Rafael D.\} and Beaupre, \{Brett A.\} and Tavares, \{Mauricio T.\} and Ferreira, \{Glaucio M.\} and Kelleher, \{Neil L.\} and Moran, \{Graham R.\} and Dali Liu and Silverman, \{Richard B.\}",

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AU - Shen, Sida

AU - Butrin, Arseniy

AU - Doubleday, Peter F.

AU - Melani, Rafael D.

AU - Beaupre, Brett A.

AU - Tavares, Mauricio T.

AU - Ferreira, Glaucio M.

AU - Kelleher, Neil L.

AU - Moran, Graham R.

AU - Liu, Dali

AU - Silverman, Richard B.

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Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase

ASJC Scopus Subject Areas

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