Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase

Sida Shen; Arseniy Butrin; Peter F. Doubleday; Rafael D. Melani; Brett A. Beaupre; Mauricio T. Tavares; Glaucio M. Ferreira; Neil L. Kelleher; Graham R. Moran; Dali Liu; Richard B. Silverman

doi:10.1021/jacs.1c02456

Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase

Sida Shen, Arseniy Butrin, Peter F. Doubleday, Rafael D. Melani, Brett A. Beaupre, Mauricio T. Tavares, Glaucio M. Ferreira, Neil L. Kelleher, Graham R. Moran, Dali Liu, Richard B. Silverman

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	8689-8703
Number of pages	15
Journal	Chemistry Faculty Research and Publications
Volume	143
Issue number	23
DOIs	https://doi.org/10.1021/jacs.1c02456
State	Published - Jun 16 2021
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/jacs.1c02456

Cite this

Shen, S., Butrin, A., Doubleday, P. F., Melani, R. D., Beaupre, B. A., Tavares, M. T., Ferreira, G. M., Kelleher, N. L., Moran, G. R., Liu, D., & Silverman, R. B. (2021). Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase. Chemistry Faculty Research and Publications, 143(23), 8689-8703. https://doi.org/10.1021/jacs.1c02456

Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase. / Shen, Sida; Butrin, Arseniy; Doubleday, Peter F. et al.
In: Chemistry Faculty Research and Publications, Vol. 143, No. 23, 16.06.2021, p. 8689-8703.

Research output: Contribution to journal › Article › peer-review

Shen, S, Butrin, A, Doubleday, PF, Melani, RD, Beaupre, BA, Tavares, MT, Ferreira, GM, Kelleher, NL, Moran, GR , Liu, D & Silverman, RB 2021, 'Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase', Chemistry Faculty Research and Publications, vol. 143, no. 23, pp. 8689-8703. https://doi.org/10.1021/jacs.1c02456

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author = "Sida Shen and Arseniy Butrin and Doubleday, \{Peter F.\} and Melani, \{Rafael D.\} and Beaupre, \{Brett A.\} and Tavares, \{Mauricio T.\} and Ferreira, \{Glaucio M.\} and Kelleher, \{Neil L.\} and Moran, \{Graham R.\} and Dali Liu and Silverman, \{Richard B.\}",

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AU - Shen, Sida

AU - Butrin, Arseniy

AU - Doubleday, Peter F.

AU - Melani, Rafael D.

AU - Beaupre, Brett A.

AU - Tavares, Mauricio T.

AU - Ferreira, Glaucio M.

AU - Kelleher, Neil L.

AU - Moran, Graham R.

AU - Liu, Dali

AU - Silverman, Richard B.

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Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase

ASJC Scopus Subject Areas

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