Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene

Christopher R. Clark; Makayla Maile; Patrick Blaney; Stefano R. Hellweg; Anna Strauss; Wilaiwan Durose; Sambhawa Priya; Juri Habicht; Michael B. Burns; Ran Blekhman; Juan E. Abrahante; Timothy K. Starr

doi:10.1038/s41598-018-33527-3

Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene

Christopher R. Clark, Makayla Maile, Patrick Blaney, Stefano R. Hellweg, Anna Strauss, Wilaiwan Durose, Sambhawa Priya, Juri Habicht, Michael B. Burns, Ran Blekhman, Juan E. Abrahante, Timothy K. Starr

Department of Biology

University of Minnesota

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-33527-3
State	Published - Dec 1 2018

Disciplines

Biology
Oncology

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@article{004d9732595b4bca9efa2926cbfcfdbf,

title = "Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene",

author = "Clark, {Christopher R.} and Makayla Maile and Patrick Blaney and Hellweg, {Stefano R.} and Anna Strauss and Wilaiwan Durose and Sambhawa Priya and Juri Habicht and Burns, {Michael B.} and Ran Blekhman and Abrahante, {Juan E.} and Starr, {Timothy K.}",

note = "New therapeutic targets for advanced colorectal cancer (CRC) are critically needed. Our laboratory recently performed an insertional mutagenesis screen in mice to identify novel CRC driver genes and, thus, potential drug targets. Here, we define Transmembrane 9 Superfamily 2 (TM9SF2) as a novel CRC oncogene.",

year = "2018",

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day = "1",

doi = "10.1038/s41598-018-33527-3",

language = "American English",

volume = "8",

journal = "Scientific Reports",

issn = "2045-2322",

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TY - JOUR

T1 - Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene

AU - Clark, Christopher R.

AU - Maile, Makayla

AU - Blaney, Patrick

AU - Hellweg, Stefano R.

AU - Strauss, Anna

AU - Durose, Wilaiwan

AU - Priya, Sambhawa

AU - Habicht, Juri

AU - Burns, Michael B.

AU - Blekhman, Ran

AU - Abrahante, Juan E.

AU - Starr, Timothy K.

N1 - New therapeutic targets for advanced colorectal cancer (CRC) are critically needed. Our laboratory recently performed an insertional mutagenesis screen in mice to identify novel CRC driver genes and, thus, potential drug targets. Here, we define Transmembrane 9 Superfamily 2 (TM9SF2) as a novel CRC oncogene.

PY - 2018/12/1

Y1 - 2018/12/1

UR - https://www.nature.com/articles/s41598-018-33527-3

U2 - 10.1038/s41598-018-33527-3

DO - 10.1038/s41598-018-33527-3

M3 - Article

SN - 2045-2322

VL - 8

JO - Scientific Reports

JF - Scientific Reports

IS - 1

ER -

Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene

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