The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites

Yash Gupta; Steven Goicoechea; Catherine M. Pearce; Raman Mathur; Jesus G. Romero; Samuel K. Kwofie; Matthew C. Weyenberg; Bharathi Daravath; Neha Sharma; Poonam; Hoseah M. Akala; Stefan M. Kanzok; Ravi Durvasula; Brijesh Rathi; Prakasha Kempaiah

doi:10.1002/med.21804

The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites

Yash Gupta, Steven Goicoechea, Catherine M. Pearce, Raman Mathur, Jesus G. Romero, Samuel K. Kwofie, Matthew C. Weyenberg, Bharathi Daravath, Neha Sharma, Poonam, Hoseah M. Akala, Stefan M. Kanzok, Ravi Durvasula, Brijesh Rathi, Prakasha Kempaiah

Research output: Contribution to journal › Review article › peer-review

Original language	English
Pages (from-to)	56-82
Number of pages	27
Journal	Medicinal Research Reviews
Volume	42
Issue number	1
DOIs	https://doi.org/10.1002/med.21804
State	Published - Jan 2022
Externally published	Yes

ASJC Scopus Subject Areas

Molecular Medicine
Pharmacology
Drug Discovery

Keywords

apicomplexa
calcium channel modulators
calcium homeostasis
cryptosporidium
drug resistance
kinetoplastida
Leishmania
Plasmodium
protozoan parasites
SERCA and non-SERCA pump inhibitors
target-based drug discovery
Toxoplasma
Trypanosoma

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10.1002/med.21804

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Gupta, Y., Goicoechea, S., Pearce, C. M., Mathur, R., Romero, J. G., Kwofie, S. K., Weyenberg, M. C., Daravath, B., Sharma, N., Poonam, Akala, H. M., Kanzok, S. M., Durvasula, R., Rathi, B., & Kempaiah, P. (2022). The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites. Medicinal Research Reviews, 42(1), 56-82. https://doi.org/10.1002/med.21804

Gupta, Y, Goicoechea, S, Pearce, CM, Mathur, R, Romero, JG, Kwofie, SK, Weyenberg, MC, Daravath, B, Sharma, N, Poonam, Akala, HM, Kanzok, SM, Durvasula, R, Rathi, B & Kempaiah, P 2022, 'The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites', Medicinal Research Reviews, vol. 42, no. 1, pp. 56-82. https://doi.org/10.1002/med.21804

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title = "The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites",

keywords = "apicomplexa, calcium channel modulators, calcium homeostasis, cryptosporidium, drug resistance, kinetoplastida, Leishmania, Plasmodium, protozoan parasites, SERCA and non-SERCA pump inhibitors, target-based drug discovery, Toxoplasma, Trypanosoma",

author = "Yash Gupta and Steven Goicoechea and Pearce, \{Catherine M.\} and Raman Mathur and Romero, \{Jesus G.\} and Kwofie, \{Samuel K.\} and Weyenberg, \{Matthew C.\} and Bharathi Daravath and Neha Sharma and Poonam and Akala, \{Hoseah M.\} and Kanzok, \{Stefan M.\} and Ravi Durvasula and Brijesh Rathi and Prakasha Kempaiah",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",

year = "2022",

month = jan,

doi = "10.1002/med.21804",

language = "English",

volume = "42",

pages = "56--82",

journal = "Medicinal Research Reviews",

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AU - Gupta, Yash

AU - Goicoechea, Steven

AU - Pearce, Catherine M.

AU - Mathur, Raman

AU - Romero, Jesus G.

AU - Kwofie, Samuel K.

AU - Weyenberg, Matthew C.

AU - Daravath, Bharathi

AU - Sharma, Neha

AU - Poonam,

AU - Akala, Hoseah M.

AU - Kanzok, Stefan M.

AU - Durvasula, Ravi

AU - Rathi, Brijesh

AU - Kempaiah, Prakasha

PY - 2022/1

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KW - apicomplexa

KW - calcium channel modulators

KW - calcium homeostasis

KW - cryptosporidium

KW - drug resistance

KW - kinetoplastida

KW - Leishmania

KW - Plasmodium

KW - protozoan parasites

KW - SERCA and non-SERCA pump inhibitors

KW - target-based drug discovery

KW - Toxoplasma

KW - Trypanosoma

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U2 - 10.1002/med.21804

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M3 - Review article

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JO - Medicinal Research Reviews

JF - Medicinal Research Reviews

IS - 1

ER -

The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites

ASJC Scopus Subject Areas

Keywords

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