Tetrazole-based inhibitors of the bacterial enzyme N-succinyl-L,L-2,6-diaminopimelic acid desuccinylase as potential antibiotics

Thomas DiPuma; Teerana Thabthimthong; Emma H. Kelley; Katherine Konczak; Megan Beulke; Claire Herbert; Thahani S. Habeeb Mohammad; Anna Starus; Boguslaw Nocek; Kenneth W. Olsen; Richard C. Holz; Daniel P. Becker

doi:10.1016/j.bmcl.2023.129177

Tetrazole-based inhibitors of the bacterial enzyme N-succinyl-L,L-2,6-diaminopimelic acid desuccinylase as potential antibiotics

Thomas DiPuma, Teerana Thabthimthong, Emma H. Kelley, Katherine Konczak, Megan Beulke, Claire Herbert, Thahani S. Habeeb Mohammad, Anna Starus, Boguslaw Nocek, Kenneth W. Olsen, Richard C. Holz, Daniel P. Becker

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	129177
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	83
DOIs	https://doi.org/10.1016/j.bmcl.2023.129177
State	Published - Mar 1 2023
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Keywords

Aminothiazole
Antibiotic
DapE
Diaminopimelate desuccinylase
Enzyme inhibition
Indoline
Ninhydrin enzyme assay
Sulfonamide
Tetrazole

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10.1016/j.bmcl.2023.129177

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DiPuma, T., Thabthimthong, T., Kelley, E. H., Konczak, K., Beulke, M., Herbert, C., S. Habeeb Mohammad, T., Starus, A., Nocek, B., Olsen, K. W., Holz, R. C., & Becker, D. P. (2023). Tetrazole-based inhibitors of the bacterial enzyme N-succinyl-L,L-2,6-diaminopimelic acid desuccinylase as potential antibiotics. Bioorganic and Medicinal Chemistry Letters, 83, Article 129177. https://doi.org/10.1016/j.bmcl.2023.129177

DiPuma, T, Thabthimthong, T, Kelley, EH, Konczak, K, Beulke, M, Herbert, C, S. Habeeb Mohammad, T, Starus, A, Nocek, B, Olsen, KW, Holz, RC & Becker, DP 2023, 'Tetrazole-based inhibitors of the bacterial enzyme N-succinyl-L,L-2,6-diaminopimelic acid desuccinylase as potential antibiotics', Bioorganic and Medicinal Chemistry Letters, vol. 83, 129177. https://doi.org/10.1016/j.bmcl.2023.129177

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title = "Tetrazole-based inhibitors of the bacterial enzyme N-succinyl-L,L-2,6-diaminopimelic acid desuccinylase as potential antibiotics",

keywords = "Aminothiazole, Antibiotic, DapE, Diaminopimelate desuccinylase, Enzyme inhibition, Indoline, Ninhydrin enzyme assay, Sulfonamide, Tetrazole",

author = "Thomas DiPuma and Teerana Thabthimthong and Kelley, \{Emma H.\} and Katherine Konczak and Megan Beulke and Claire Herbert and \{S. Habeeb Mohammad\}, Thahani and Anna Starus and Boguslaw Nocek and Olsen, \{Kenneth W.\} and Holz, \{Richard C.\} and Becker, \{Daniel P.\}",

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year = "2023",

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doi = "10.1016/j.bmcl.2023.129177",

language = "English",

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T1 - Tetrazole-based inhibitors of the bacterial enzyme N-succinyl-L,L-2,6-diaminopimelic acid desuccinylase as potential antibiotics

AU - DiPuma, Thomas

AU - Thabthimthong, Teerana

AU - Kelley, Emma H.

AU - Konczak, Katherine

AU - Beulke, Megan

AU - Herbert, Claire

AU - S. Habeeb Mohammad, Thahani

AU - Starus, Anna

AU - Nocek, Boguslaw

AU - Olsen, Kenneth W.

AU - Holz, Richard C.

AU - Becker, Daniel P.

PY - 2023/3/1

Y1 - 2023/3/1

KW - Aminothiazole

KW - Antibiotic

KW - DapE

KW - Diaminopimelate desuccinylase

KW - Enzyme inhibition

KW - Indoline

KW - Ninhydrin enzyme assay

KW - Sulfonamide

KW - Tetrazole

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DO - 10.1016/j.bmcl.2023.129177

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VL - 83

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Tetrazole-based inhibitors of the bacterial enzyme N-succinyl-L,L-2,6-diaminopimelic acid desuccinylase as potential antibiotics

ASJC Scopus Subject Areas

Keywords

Access to Document

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