Tetrazole-based inhibitors of the bacterial enzyme N-succinyl-L,L-2,6-diaminopimelic acid desuccinylase as potential antibiotics

  • Thomas DiPuma
  • , Teerana Thabthimthong
  • , Emma H. Kelley
  • , Katherine Konczak
  • , Megan Beulke
  • , Claire Herbert
  • , Thahani S. Habeeb Mohammad
  • , Anna Starus
  • , Boguslaw Nocek
  • , Kenneth W. Olsen
  • , Richard C. Holz
  • , Daniel P. Becker

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number129177
JournalBioorganic and Medicinal Chemistry Letters
Volume83
DOIs
StatePublished - Mar 1 2023
Externally publishedYes

ASJC Scopus Subject Areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Keywords

  • Aminothiazole
  • Antibiotic
  • DapE
  • Diaminopimelate desuccinylase
  • Enzyme inhibition
  • Indoline
  • Ninhydrin enzyme assay
  • Sulfonamide
  • Tetrazole

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