Synthesis of Pyrazole-Based Inhibitors of the Bacterial Enzyme N-Succinyl-l,l-2,6-Diaminopimelic Acid Desuccinylase (DapE) as Potential Antibiotics

Thomas DiPuma; Emma H. Kelley; Teerana Thabthimthong; Alayna Bland; Katherine Konczak; Katherine J. Torma; Thahani S.Habeeb Mohammad; Kenneth W. Olsen; Daniel P. Becker

doi:10.3390/ijms26010022

Synthesis of Pyrazole-Based Inhibitors of the Bacterial Enzyme N-Succinyl-l,l-2,6-Diaminopimelic Acid Desuccinylase (DapE) as Potential Antibiotics

Thomas DiPuma, Emma H. Kelley, Teerana Thabthimthong, Alayna Bland, Katherine Konczak, Katherine J. Torma, Thahani S.Habeeb Mohammad, Kenneth W. Olsen, Daniel P. Becker

Loyola University of Chicago

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	22
Journal	International Journal of Molecular Sciences
Volume	26
Issue number	1
DOIs	https://doi.org/10.3390/ijms26010022
State	Published - Jan 2025
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

Keywords

antibiotic
DapE
metalloenzyme
ninhydrin

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10.3390/ijms26010022

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DiPuma, T., Kelley, E. H., Thabthimthong, T., Bland, A., Konczak, K., Torma, K. J., Mohammad, T. S. H., Olsen, K. W., & Becker, D. P. (2025). Synthesis of Pyrazole-Based Inhibitors of the Bacterial Enzyme N-Succinyl-l,l-2,6-Diaminopimelic Acid Desuccinylase (DapE) as Potential Antibiotics. International Journal of Molecular Sciences, 26(1), Article 22. https://doi.org/10.3390/ijms26010022

DiPuma, T, Kelley, EH, Thabthimthong, T, Bland, A, Konczak, K, Torma, KJ, Mohammad, TSH, Olsen, KW & Becker, DP 2025, 'Synthesis of Pyrazole-Based Inhibitors of the Bacterial Enzyme N-Succinyl-l,l-2,6-Diaminopimelic Acid Desuccinylase (DapE) as Potential Antibiotics', International Journal of Molecular Sciences, vol. 26, no. 1, 22. https://doi.org/10.3390/ijms26010022

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title = "Synthesis of Pyrazole-Based Inhibitors of the Bacterial Enzyme N-Succinyl-l,l-2,6-Diaminopimelic Acid Desuccinylase (DapE) as Potential Antibiotics",

keywords = "antibiotic, DapE, metalloenzyme, ninhydrin",

author = "Thomas DiPuma and Kelley, \{Emma H.\} and Teerana Thabthimthong and Alayna Bland and Katherine Konczak and Torma, \{Katherine J.\} and Mohammad, \{Thahani S.Habeeb\} and Olsen, \{Kenneth W.\} and Becker, \{Daniel P.\}",

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AU - DiPuma, Thomas

AU - Kelley, Emma H.

AU - Thabthimthong, Teerana

AU - Bland, Alayna

AU - Konczak, Katherine

AU - Torma, Katherine J.

AU - Mohammad, Thahani S.Habeeb

AU - Olsen, Kenneth W.

AU - Becker, Daniel P.

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KW - DapE

KW - metalloenzyme

KW - ninhydrin

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JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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Synthesis of Pyrazole-Based Inhibitors of the Bacterial Enzyme N-Succinyl-l,l-2,6-Diaminopimelic Acid Desuccinylase (DapE) as Potential Antibiotics

ASJC Scopus Subject Areas

Keywords

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