Substitution of the Thioredoxin System for Glutathione Reductase in Drosophila melanogaster

Stefan M. Kanzok; Anke Fechner; Holger Bauer; Julia K. Ulschmid; Hans-Michael Müller; José Botella-Munoz; Stephan Schneuwly; R. Heiner Schirmer; Katja Becker

doi:10.1126/science.291.5504.643

Substitution of the Thioredoxin System for Glutathione Reductase in Drosophila melanogaster

Stefan M. Kanzok
, Anke Fechner
, Holger Bauer
, Julia K. Ulschmid
, Hans-Michael Müller
, José Botella-Munoz
, Stephan Schneuwly
, R. Heiner Schirmer
, Katja Becker

Heidelberg University
2 Interdisciplinary Research Center, Heinrich-Buff-Ring 26-32, Giessen University, D-35392 Giessen, Germany.
3 European Molecular Biology Laboratory, D-69117 Heidelberg, Germany.
University of Regensburg

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Science
Volume	291
Issue number	5504
DOIs	https://doi.org/10.1126/science.291.5504.643
State	Published - Jan 26 2001
Externally published	Yes

Disciplines

Biochemistry
Biology

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10.1126/science.291.5504.643License: Unspecified

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@article{140f5b8d80ae409aa0b167e31f3164cb,

title = "Substitution of the Thioredoxin System for Glutathione Reductase in Drosophila melanogaster",

author = "Kanzok, \{Stefan M.\} and Anke Fechner and Holger Bauer and Ulschmid, \{Julia K.\} and Hans-Michael M{\"u}ller and Jos{\'e} Botella-Munoz and Stephan Schneuwly and Schirmer, \{R. Heiner\} and Katja Becker",

note = "The disulfide reducing enzymes glutathione reductase and thioredoxin reductase are highly conserved among bacteria, fungi, worms, and mammals. These proteins maintain intracellular redox homeostasis to protect the organism from oxidative damage. Here we demonstrate the absence of glutathione reductase in Drosophila melanogaster , identify a new type of thioredoxin reductase, and provide evidence that a thioredoxin system supports GSSG reduction.",

year = "2001",

month = jan,

day = "26",

doi = "10.1126/science.291.5504.643",

language = "American English",

volume = "291",

journal = "Science",

issn = "1095-9203",

number = "5504",

}

TY - JOUR

T1 - Substitution of the Thioredoxin System for Glutathione Reductase in Drosophila melanogaster

AU - Kanzok, Stefan M.

AU - Fechner, Anke

AU - Bauer, Holger

AU - Ulschmid, Julia K.

AU - Müller, Hans-Michael

AU - Botella-Munoz, José

AU - Schneuwly, Stephan

AU - Schirmer, R. Heiner

AU - Becker, Katja

N1 - The disulfide reducing enzymes glutathione reductase and thioredoxin reductase are highly conserved among bacteria, fungi, worms, and mammals. These proteins maintain intracellular redox homeostasis to protect the organism from oxidative damage. Here we demonstrate the absence of glutathione reductase in Drosophila melanogaster , identify a new type of thioredoxin reductase, and provide evidence that a thioredoxin system supports GSSG reduction.

PY - 2001/1/26

Y1 - 2001/1/26

UR - http://science.sciencemag.org/content/291/5504/643.full

U2 - 10.1126/science.291.5504.643

DO - 10.1126/science.291.5504.643

M3 - Article

SN - 1095-9203

VL - 291

JO - Science

JF - Science

IS - 5504

ER -

Substitution of the Thioredoxin System for Glutathione Reductase in Drosophila melanogaster

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