Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid

Sida Shen; Arseniy Butrin; Brett A. Beaupre; Glaucio M. Ferreira; Peter F. Doubleday; Daniel H. Grass; Wei Zhu; Neil L. Kelleher; Graham R. Moran; Dali Liu; Richard B. Silverman

doi:10.3390/molecules28031133

Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid

Sida Shen, Arseniy Butrin, Brett A. Beaupre, Glaucio M. Ferreira, Peter F. Doubleday, Daniel H. Grass, Wei Zhu, Neil L. Kelleher, Graham R. Moran, Dali Liu, Richard B. Silverman

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	1133
Journal	Molecules
Volume	28
Issue number	3
DOIs	https://doi.org/10.3390/molecules28031133
State	Published - Feb 2023
Externally published	Yes

ASJC Scopus Subject Areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

Keywords

aminotransferase
cyclopentene
enamine
mechanism-based inactivators
mechanistic studies

Access to Document

10.3390/molecules28031133

Cite this

Shen, S., Butrin, A., Beaupre, B. A., Ferreira, G. M., Doubleday, P. F., Grass, D. H., Zhu, W., Kelleher, N. L., Moran, G. R., Liu, D., & Silverman, R. B. (2023). Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid. Molecules, 28(3), Article 1133. https://doi.org/10.3390/molecules28031133

@article{ddbe4f6ce70d465f94af12f7e1ffcef6,

title = "Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid",

keywords = "aminotransferase, cyclopentene, enamine, mechanism-based inactivators, mechanistic studies",

author = "Sida Shen and Arseniy Butrin and Beaupre, \{Brett A.\} and Ferreira, \{Glaucio M.\} and Doubleday, \{Peter F.\} and Grass, \{Daniel H.\} and Wei Zhu and Kelleher, \{Neil L.\} and Moran, \{Graham R.\} and Dali Liu and Silverman, \{Richard B.\}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = feb,

doi = "10.3390/molecules28031133",

language = "English",

volume = "28",

journal = "Molecules",

issn = "1420-3049",

number = "3",

}

TY - JOUR

T1 - Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid

AU - Shen, Sida

AU - Butrin, Arseniy

AU - Beaupre, Brett A.

AU - Ferreira, Glaucio M.

AU - Doubleday, Peter F.

AU - Grass, Daniel H.

AU - Zhu, Wei

AU - Kelleher, Neil L.

AU - Moran, Graham R.

AU - Liu, Dali

AU - Silverman, Richard B.

PY - 2023/2

Y1 - 2023/2

KW - aminotransferase

KW - cyclopentene

KW - enamine

KW - mechanism-based inactivators

KW - mechanistic studies

UR - https://www.scopus.com/pages/publications/85147892457

UR - https://www.scopus.com/inward/citedby.url?scp=85147892457&partnerID=8YFLogxK

U2 - 10.3390/molecules28031133

DO - 10.3390/molecules28031133

M3 - Article

C2 - 36770800

AN - SCOPUS:85147892457

SN - 1420-3049

VL - 28

JO - Molecules

JF - Molecules

IS - 3

M1 - 1133

ER -

Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid

ASJC Scopus Subject Areas

Keywords

Access to Document

Other files and links

Cite this