Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid

  • Sida Shen
  • , Arseniy Butrin
  • , Brett A. Beaupre
  • , Glaucio M. Ferreira
  • , Peter F. Doubleday
  • , Daniel H. Grass
  • , Wei Zhu
  • , Neil L. Kelleher
  • , Graham R. Moran
  • , Dali Liu
  • , Richard B. Silverman

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number1133
JournalMolecules
Volume28
Issue number3
DOIs
StatePublished - Feb 2023
Externally publishedYes

ASJC Scopus Subject Areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Keywords

  • aminotransferase
  • cyclopentene
  • enamine
  • mechanism-based inactivators
  • mechanistic studies

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