Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid

Sida Shen, Arseniy Butrin, Brett A. Beaupre, Glaucio M. Ferreira, Peter F. Doubleday, Daniel H. Grass, Wei Zhu, Neil L. Kelleher, Graham R. Moran, Dali Liu, Richard B. Silverman

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number1133
JournalMolecules
Volume28
Issue number3
DOIs
StatePublished - Feb 2023
Externally publishedYes

ASJC Scopus Subject Areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Keywords

  • aminotransferase
  • cyclopentene
  • enamine
  • mechanism-based inactivators
  • mechanistic studies

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