Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1 S,3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF3)

Arseniy Butrin; Brett A. Beaupre; Noel Kadamandla; Peidong Zhao; Sida Shen; Richard B. Silverman; Graham R. Moran; Dali Liu

doi:10.1021/acschembio.0c00728

Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1 S,3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF₃)

Arseniy Butrin, Brett A. Beaupre, Noel Kadamandla, Peidong Zhao, Sida Shen, Richard B. Silverman, Graham R. Moran, Dali Liu

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	67-75
Number of pages	9
Journal	ACS Chemical Biology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1021/acschembio.0c00728
State	Published - Jan 15 2021
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine

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10.1021/acschembio.0c00728

Cite this

Butrin, A., Beaupre, B. A., Kadamandla, N., Zhao, P., Shen, S., Silverman, R. B., Moran, G. R., & Liu, D. (2021). Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1 S,3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF₃). ACS Chemical Biology, 16(1), 67-75. https://doi.org/10.1021/acschembio.0c00728

Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1 S,3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF₃). / Butrin, Arseniy; Beaupre, Brett A.; Kadamandla, Noel et al.
In: ACS Chemical Biology, Vol. 16, No. 1, 15.01.2021, p. 67-75.

Research output: Contribution to journal › Article › peer-review

Butrin, A, Beaupre, BA, Kadamandla, N, Zhao, P, Shen, S, Silverman, RB, Moran, GR & Liu, D 2021, 'Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1 S,3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF₃)', ACS Chemical Biology, vol. 16, no. 1, pp. 67-75. https://doi.org/10.1021/acschembio.0c00728

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AU - Beaupre, Brett A.

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AU - Zhao, Peidong

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AU - Silverman, Richard B.

AU - Moran, Graham R.

AU - Liu, Dali

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Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1 S,3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF3)

ASJC Scopus Subject Areas

Access to Document

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Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1 S,3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF₃)