Spectroscopic and computational studies of NTBC bound to the non-heme iron enzyme (4-hydroxyphenyl)pyruvate dioxygenase: Active site contributions to drug inhibition

Michael L. Neidig, Andrea Decker, Michael Kavana, Graham R. Moran, Edward I. Solomon

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)206-214
Number of pages9
JournalChemistry Faculty Research and Publications
Volume338
Issue number1
DOIs
StatePublished - Dec 9 2005
Externally publishedYes

ASJC Scopus Subject Areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Keywords

  • α-Ketoglutarate dioxygenases
  • (4-Hydroxyphenyl)pyruvate dioxygenase
  • Density function theory
  • Drug inhibition
  • Magnetic circular dichroism
  • Non-heme iron
  • Structure-activity relationships

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