Serotonin 5-HT4 Agonist Activity of a Series of Meso-Azanoradamantane Benzamides

Daniel Becker; Roger Nosal; Clara I. Villamil; Gary Gullikson

doi:10.1016/S0960-894X(97)00408-3

Serotonin 5-HT4 Agonist Activity of a Series of Meso-Azanoradamantane Benzamides

Daniel Becker, Roger Nosal, Clara I. Villamil, Gary Gullikson

Department of Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4agonist in the series, with an EC50 of 217 nM.

Original language	American English
Journal	Chemistry: Faculty Publications and Other Works
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/S0960-894X(97)00408-3
State	Published - Sep 9 1997

Keywords

Serotonin
benzamides

Disciplines

Chemistry

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Serotonin 5-HT4 Agonist Activity of a Series of Meso-AzanoradamaFinal published version, 128 KBLicense: Unspecified

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title = "Serotonin 5-HT4 Agonist Activity of a Series of Meso-Azanoradamantane Benzamides",

abstract = " A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4agonist in the series, with an EC50 of 217 nM.",

keywords = "Serotonin, benzamides",

author = "Daniel Becker and Roger Nosal and Villamil, {Clara I.} and Gary Gullikson",

year = "1997",

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T1 - Serotonin 5-HT4 Agonist Activity of a Series of Meso-Azanoradamantane Benzamides

AU - Becker, Daniel

AU - Nosal, Roger

AU - Villamil, Clara I.

AU - Gullikson, Gary

PY - 1997/9/9

Y1 - 1997/9/9

N2 - A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4agonist in the series, with an EC50 of 217 nM.

AB - A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4agonist in the series, with an EC50 of 217 nM.

KW - Serotonin

KW - benzamides

UR - https://ecommons.luc.edu/chemistry_facpubs/15

U2 - 10.1016/S0960-894X(97)00408-3

DO - 10.1016/S0960-894X(97)00408-3

M3 - Article

VL - 17

JO - Chemistry: Faculty Publications and Other Works

JF - Chemistry: Faculty Publications and Other Works

IS - 1

ER -

Serotonin 5-HT4 Agonist Activity of a Series of Meso-Azanoradamantane Benzamides

Abstract

Keywords

Disciplines

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