Selective, Orally Active MMP Inhibitors with an Aryl Backbone

Thomas Barta; Daniel P. Becker; Louis J. Bedell; Gary A. De Crescenzo

doi:10.1016/S0960-894X(01)00487-5

Selective, Orally Active MMP Inhibitors with an Aryl Backbone

Thomas Barta, Daniel P. Becker, Louis J. Bedell, Gary A. De Crescenzo

Department of Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

This letter describes SAR exploration and rat PK optimization of a series of novel, MMP-1 sparing aryl hydroxamate sulfonamides with activity against MMP-2 and MMP-13.

Original language	American English
Journal	Chemistry: Faculty Publications and Other Works
Volume	11
Issue number	18
DOIs	https://doi.org/10.1016/S0960-894X(01)00487-5
State	Published - Sep 17 2001

Keywords

aryl backbone
orally active MMP inhibitors

Disciplines

Chemistry

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Cite this

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title = "Selective, Orally Active MMP Inhibitors with an Aryl Backbone",

abstract = " This letter describes SAR exploration and rat PK optimization of a series of novel, MMP-1 sparing aryl hydroxamate sulfonamides with activity against MMP-2 and MMP-13.",

keywords = "aryl backbone, orally active MMP inhibitors",

author = "Thomas Barta and Becker, {Daniel P.} and Bedell, {Louis J.} and {De Crescenzo}, {Gary A.}",

year = "2001",

month = sep,

day = "17",

doi = "10.1016/S0960-894X(01)00487-5",

language = "American English",

volume = "11",

journal = "Chemistry: Faculty Publications and Other Works",

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TY - JOUR

T1 - Selective, Orally Active MMP Inhibitors with an Aryl Backbone

AU - Barta, Thomas

AU - Becker, Daniel P.

AU - Bedell, Louis J.

AU - De Crescenzo, Gary A.

PY - 2001/9/17

Y1 - 2001/9/17

N2 - This letter describes SAR exploration and rat PK optimization of a series of novel, MMP-1 sparing aryl hydroxamate sulfonamides with activity against MMP-2 and MMP-13.

AB - This letter describes SAR exploration and rat PK optimization of a series of novel, MMP-1 sparing aryl hydroxamate sulfonamides with activity against MMP-2 and MMP-13.

KW - aryl backbone

KW - orally active MMP inhibitors

UR - https://ecommons.luc.edu/chemistry_facpubs/19

U2 - 10.1016/S0960-894X(01)00487-5

DO - 10.1016/S0960-894X(01)00487-5

M3 - Article

VL - 11

JO - Chemistry: Faculty Publications and Other Works

JF - Chemistry: Faculty Publications and Other Works

IS - 18

ER -

Selective, Orally Active MMP Inhibitors with an Aryl Backbone

Abstract

Keywords

Disciplines

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