SC-53116: The First Selective Agonist at the Newly Identified Serotonin 5-HT4 Receptor Subtype

Daniel L. Flynn; Daniel Zabrowski; Daniel Becker; Roger Nosal

doi:10.1021/jm00086a019

SC-53116: The First Selective Agonist at the Newly Identified Serotonin 5-HT4 Receptor Subtype

Daniel L. Flynn
, Daniel Zabrowski
, Daniel Becker
, Roger Nosal

Department of Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Serotonin acts as a neurotransmitter, neuromodulator, and hormone in mammals, and it is known to exhibit profound pharmacological activities in the central nervous system, autonomic nervous system, enteric nervous system, and cardiovascular system. Among monoamine neuro-transmitters, serotonin is unsurpassed in the number of receptor subtypes identified. Until recently, serotonin was thought to act through receptors subtyped as 5-HT1, 5-HT2, and 5-HT3. Furthermore, even these subtypes have been subclassed to now include 5-HT1A, 5-HT1B, 5-HTlc, 5-HT1D, 5-HT2A, 5-HT2B, and 5-HT3A ,5-HT3B ,and 5-HT33C.2

Original language	American English
Journal	Chemistry: Faculty Publications and Other Works
Volume	35
Issue number	8
DOIs	https://doi.org/10.1021/jm00086a019
State	Published - Mar 1 1992

Keywords

serotonin
neurotransmitter
neuromodulator
selective agonist

Disciplines

Chemistry

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Cite this

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title = "SC-53116: The First Selective Agonist at the Newly Identified Serotonin 5-HT4 Receptor Subtype",

abstract = " Serotonin acts as a neurotransmitter, neuromodulator, and hormone in mammals, and it is known to exhibit profound pharmacological activities in the central nervous system, autonomic nervous system, enteric nervous system, and cardiovascular system. Among monoamine neuro-transmitters, serotonin is unsurpassed in the number of receptor subtypes identified. Until recently, serotonin was thought to act through receptors subtyped as 5-HT1, 5-HT2, and 5-HT3. Furthermore, even these subtypes have been subclassed to now include 5-HT1A, 5-HT1B, 5-HTlc, 5-HT1D, 5-HT2A, 5-HT2B, and 5-HT3A ,5-HT3B ,and 5-HT33C.2",

keywords = "serotonin, neurotransmitter, neuromodulator, selective agonist",

author = "Flynn, \{Daniel L.\} and Daniel Zabrowski and Daniel Becker and Roger Nosal",

year = "1992",

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doi = "10.1021/jm00086a019",

language = "American English",

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journal = "Chemistry: Faculty Publications and Other Works",

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T1 - SC-53116: The First Selective Agonist at the Newly Identified Serotonin 5-HT4 Receptor Subtype

AU - Flynn, Daniel L.

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AU - Becker, Daniel

AU - Nosal, Roger

PY - 1992/3/1

Y1 - 1992/3/1

N2 - Serotonin acts as a neurotransmitter, neuromodulator, and hormone in mammals, and it is known to exhibit profound pharmacological activities in the central nervous system, autonomic nervous system, enteric nervous system, and cardiovascular system. Among monoamine neuro-transmitters, serotonin is unsurpassed in the number of receptor subtypes identified. Until recently, serotonin was thought to act through receptors subtyped as 5-HT1, 5-HT2, and 5-HT3. Furthermore, even these subtypes have been subclassed to now include 5-HT1A, 5-HT1B, 5-HTlc, 5-HT1D, 5-HT2A, 5-HT2B, and 5-HT3A ,5-HT3B ,and 5-HT33C.2

AB - Serotonin acts as a neurotransmitter, neuromodulator, and hormone in mammals, and it is known to exhibit profound pharmacological activities in the central nervous system, autonomic nervous system, enteric nervous system, and cardiovascular system. Among monoamine neuro-transmitters, serotonin is unsurpassed in the number of receptor subtypes identified. Until recently, serotonin was thought to act through receptors subtyped as 5-HT1, 5-HT2, and 5-HT3. Furthermore, even these subtypes have been subclassed to now include 5-HT1A, 5-HT1B, 5-HTlc, 5-HT1D, 5-HT2A, 5-HT2B, and 5-HT3A ,5-HT3B ,and 5-HT33C.2

KW - serotonin

KW - neurotransmitter

KW - neuromodulator

KW - selective agonist

UR - https://ecommons.luc.edu/chemistry_facpubs/5

U2 - 10.1021/jm00086a019

DO - 10.1021/jm00086a019

M3 - Article

VL - 35

JO - Chemistry: Faculty Publications and Other Works

JF - Chemistry: Faculty Publications and Other Works

IS - 8

ER -

SC-53116: The First Selective Agonist at the Newly Identified Serotonin 5-HT4 Receptor Subtype

Abstract

Keywords

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