TY - JOUR
T1 - SC-53116: The First Selective Agonist at the Newly Identified Serotonin 5-HT4 Receptor Subtype
AU - Flynn, Daniel L.
AU - Zabrowski, Daniel
AU - Becker, Daniel
AU - Nosal, Roger
PY - 1992/3/1
Y1 - 1992/3/1
N2 - Serotonin acts as a neurotransmitter, neuromodulator, and hormone in mammals, and it is known to exhibit profound pharmacological activities in the central nervous system, autonomic nervous system, enteric nervous system, and cardiovascular system. Among monoamine neuro-transmitters, serotonin is unsurpassed in the number of receptor subtypes identified. Until recently, serotonin was thought to act through receptors subtyped as 5-HT1, 5-HT2, and 5-HT3. Furthermore, even these subtypes have been subclassed to now include 5-HT1A, 5-HT1B, 5-HTlc, 5-HT1D, 5-HT2A, 5-HT2B, and 5-HT3A ,5-HT3B ,and 5-HT33C.2
AB - Serotonin acts as a neurotransmitter, neuromodulator, and hormone in mammals, and it is known to exhibit profound pharmacological activities in the central nervous system, autonomic nervous system, enteric nervous system, and cardiovascular system. Among monoamine neuro-transmitters, serotonin is unsurpassed in the number of receptor subtypes identified. Until recently, serotonin was thought to act through receptors subtyped as 5-HT1, 5-HT2, and 5-HT3. Furthermore, even these subtypes have been subclassed to now include 5-HT1A, 5-HT1B, 5-HTlc, 5-HT1D, 5-HT2A, 5-HT2B, and 5-HT3A ,5-HT3B ,and 5-HT33C.2
KW - serotonin
KW - neurotransmitter
KW - neuromodulator
KW - selective agonist
UR - https://ecommons.luc.edu/chemistry_facpubs/5
U2 - 10.1021/jm00086a019
DO - 10.1021/jm00086a019
M3 - Article
VL - 35
JO - Chemistry: Faculty Publications and Other Works
JF - Chemistry: Faculty Publications and Other Works
IS - 8
ER -