Repurposing Lansoprazole and Posaconazole to treat leishmaniasis: Integration of in vitro testing, pharmacological corroboration, and mechanisms of action

Yash Gupta; Steven Goicoechea; Jesus G. Romero; Raman Mathur; Thomas R. Caulfield; Daniel P. Becker; Ravi Durvasula; Prakasha Kempaiah

doi:10.38212/2224-6614.3394

Repurposing Lansoprazole and Posaconazole to treat leishmaniasis: Integration of in vitro testing, pharmacological corroboration, and mechanisms of action

Yash Gupta
, Steven Goicoechea
, Jesus G. Romero
, Raman Mathur
, Thomas R. Caulfield
, Daniel P. Becker
, Ravi Durvasula
, Prakasha Kempaiah

Mayo Clinic in Jacksonville, Florida
Stritch School of Medicine
Central University of Venezuela
Mayo Clinic Graduate School of Biomedical Sciences
Loyola University of Chicago

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	11
Pages (from-to)	128-149
Number of pages	22
Journal	Journal of Food and Drug Analysis
Volume	30
Issue number	1
DOIs	https://doi.org/10.38212/2224-6614.3394
State	Published - 2022
Externally published	Yes

ASJC Scopus Subject Areas

Food Science
Pharmacology

Keywords

Drug repurposing
Lansoprazole
Leishmaniasis
Molecular dynamics
Posaconazole

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10.38212/2224-6614.3394

Cite this

Gupta, Y., Goicoechea, S., Romero, J. G., Mathur, R., Caulfield, T. R., Becker, D. P., Durvasula, R., & Kempaiah, P. (2022). Repurposing Lansoprazole and Posaconazole to treat leishmaniasis: Integration of in vitro testing, pharmacological corroboration, and mechanisms of action. Journal of Food and Drug Analysis, 30(1), 128-149. Article 11. https://doi.org/10.38212/2224-6614.3394

Gupta, Y, Goicoechea, S, Romero, JG, Mathur, R, Caulfield, TR, Becker, DP, Durvasula, R & Kempaiah, P 2022, 'Repurposing Lansoprazole and Posaconazole to treat leishmaniasis: Integration of in vitro testing, pharmacological corroboration, and mechanisms of action', Journal of Food and Drug Analysis, vol. 30, no. 1, 11, pp. 128-149. https://doi.org/10.38212/2224-6614.3394

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AU - Goicoechea, Steven

AU - Romero, Jesus G.

AU - Mathur, Raman

AU - Caulfield, Thomas R.

AU - Becker, Daniel P.

AU - Durvasula, Ravi

AU - Kempaiah, Prakasha

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KW - Drug repurposing

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KW - Molecular dynamics

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Repurposing Lansoprazole and Posaconazole to treat leishmaniasis: Integration of in vitro testing, pharmacological corroboration, and mechanisms of action

ASJC Scopus Subject Areas

Keywords

Access to Document

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