Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase

Wei Zhu; Peter F. Doubleday; Arseniy Butrin; Pathum M. Weerawarna; Rafael D. Melani; Daniel S. Catlin; Timothy A. Dwight; Dali Liu; Neil L. Kelleher; Richard B. Silverman

doi:10.1021/jacs.1c03572

Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase

Wei Zhu, Peter F. Doubleday, Arseniy Butrin, Pathum M. Weerawarna, Rafael D. Melani, Daniel S. Catlin, Timothy A. Dwight, Dali Liu, Neil L. Kelleher, Richard B. Silverman

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	8193-8207
Number of pages	15
Journal	Chemistry Faculty Research and Publications
Volume	143
Issue number	21
DOIs	https://doi.org/10.1021/jacs.1c03572
State	Published - Jun 2 2021
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/jacs.1c03572

Cite this

Zhu, W., Doubleday, P. F., Butrin, A., Weerawarna, P. M., Melani, R. D., Catlin, D. S., Dwight, T. A., Liu, D., Kelleher, N. L., & Silverman, R. B. (2021). Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. Chemistry Faculty Research and Publications, 143(21), 8193-8207. https://doi.org/10.1021/jacs.1c03572

Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. / Zhu, Wei; Doubleday, Peter F.; Butrin, Arseniy et al.
In: Chemistry Faculty Research and Publications, Vol. 143, No. 21, 02.06.2021, p. 8193-8207.

Research output: Contribution to journal › Article › peer-review

Zhu, W, Doubleday, PF, Butrin, A, Weerawarna, PM, Melani, RD, Catlin, DS, Dwight, TA, Liu, D, Kelleher, NL & Silverman, RB 2021, 'Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase', Chemistry Faculty Research and Publications, vol. 143, no. 21, pp. 8193-8207. https://doi.org/10.1021/jacs.1c03572

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author = "Wei Zhu and Doubleday, \{Peter F.\} and Arseniy Butrin and Weerawarna, \{Pathum M.\} and Melani, \{Rafael D.\} and Catlin, \{Daniel S.\} and Dwight, \{Timothy A.\} and Dali Liu and Kelleher, \{Neil L.\} and Silverman, \{Richard B.\}",

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AU - Butrin, Arseniy

AU - Weerawarna, Pathum M.

AU - Melani, Rafael D.

AU - Catlin, Daniel S.

AU - Dwight, Timothy A.

AU - Liu, Dali

AU - Kelleher, Neil L.

AU - Silverman, Richard B.

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Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase

ASJC Scopus Subject Areas

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