Rational Design, Synthesis, and Mechanism of (3 S,4 R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase

Wei Zhu; Arseniy Butrin; Rafael D. Melani; Peter F. Doubleday; Glaucio Monteiro Ferreira; Mauricio T. Tavares; Thahani S. Habeeb Mohammad; Brett A. Beaupre; Neil L. Kelleher; Graham R. Moran; Dali Liu; Richard B. Silverman

doi:10.1021/jacs.2c00924

Rational Design, Synthesis, and Mechanism of (3 S,4 R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase

Wei Zhu
, Arseniy Butrin
, Rafael D. Melani
, Peter F. Doubleday
, Glaucio Monteiro Ferreira
, Mauricio T. Tavares
, Thahani S. Habeeb Mohammad
, Brett A. Beaupre
, Neil L. Kelleher
, Graham R. Moran
, Dali Liu
, Richard B. Silverman

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	5629-5642
Number of pages	14
Journal	Chemistry Faculty Research and Publications
Volume	144
Issue number	12
DOIs	https://doi.org/10.1021/jacs.2c00924
State	Published - Mar 30 2022
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

Access to Document

10.1021/jacs.2c00924

Cite this

Zhu, W., Butrin, A., Melani, R. D., Doubleday, P. F., Ferreira, G. M., Tavares, M. T., Habeeb Mohammad, T. S., Beaupre, B. A., Kelleher, N. L., Moran, G. R., Liu, D., & Silverman, R. B. (2022). Rational Design, Synthesis, and Mechanism of (3 S,4 R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase. Chemistry Faculty Research and Publications, 144(12), 5629-5642. https://doi.org/10.1021/jacs.2c00924

Rational Design, Synthesis, and Mechanism of (3 S,4 R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase. / Zhu, Wei; Butrin, Arseniy; Melani, Rafael D. et al.
In: Chemistry Faculty Research and Publications, Vol. 144, No. 12, 30.03.2022, p. 5629-5642.

Research output: Contribution to journal › Article › peer-review

Zhu, W, Butrin, A, Melani, RD, Doubleday, PF, Ferreira, GM, Tavares, MT, Habeeb Mohammad, TS, Beaupre, BA, Kelleher, NL, Moran, GR , Liu, D & Silverman, RB 2022, 'Rational Design, Synthesis, and Mechanism of (3 S,4 R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase', Chemistry Faculty Research and Publications, vol. 144, no. 12, pp. 5629-5642. https://doi.org/10.1021/jacs.2c00924

Zhu W, Butrin A, Melani RD, Doubleday PF, Ferreira GM, Tavares MT et al. Rational Design, Synthesis, and Mechanism of (3 S,4 R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase. Chemistry Faculty Research and Publications. 2022 Mar 30;144(12):5629-5642. doi: 10.1021/jacs.2c00924

Zhu, Wei ; Butrin, Arseniy ; Melani, Rafael D. et al. / Rational Design, Synthesis, and Mechanism of (3 S,4 R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid : Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase. In: Chemistry Faculty Research and Publications. 2022 ; Vol. 144, No. 12. pp. 5629-5642.

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Rational Design, Synthesis, and Mechanism of (3 S,4 R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase

ASJC Scopus Subject Areas

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