Proteome Association Studies in Populations of Diverse Ancestries

Isabelle Gregga; Elyse Geoffroy; Ryan Schubert; Heather Wheeler

Proteome Association Studies in Populations of Diverse Ancestries

Isabelle Gregga, Elyse Geoffroy, Ryan Schubert, Heather Wheeler

Department of Biology

Loyola University Chicago

Research output: Contribution to journal › Article › peer-review

Abstract

Most GWAS have been conducted in populations of European ancestries, but these results do not reflect the global population or replicate well in non-European populations. Additionally, investigating traits at the proteome level may provide more insight to biological mechanisms than at the genome level. Using data from the TOPMed consortium, we have built protein models to perform PWAS using S-PrediXcan in published multiethnic GWAS data from the PAGE study (Wojcik et al 2019). This output reveals significant associations between genes and a variety of complex traits in non-European populations.

Original language	American English
Journal	Undergraduate Research and Engagement Symposium
State	Published - 1800

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title = "Proteome Association Studies in Populations of Diverse Ancestries",

abstract = " Most GWAS have been conducted in populations of European ancestries, but these results do not reflect the global population or replicate well in non-European populations. Additionally, investigating traits at the proteome level may provide more insight to biological mechanisms than at the genome level. Using data from the TOPMed consortium, we have built protein models to perform PWAS using S-PrediXcan in published multiethnic GWAS data from the PAGE study (Wojcik et al 2019). This output reveals significant associations between genes and a variety of complex traits in non-European populations.",

author = "Isabelle Gregga and Elyse Geoffroy and Ryan Schubert and Heather Wheeler",

year = "1800",

language = "American English",

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T1 - Proteome Association Studies in Populations of Diverse Ancestries

AU - Gregga, Isabelle

AU - Geoffroy, Elyse

AU - Schubert, Ryan

AU - Wheeler, Heather

PY - 1800

Y1 - 1800

N2 - Most GWAS have been conducted in populations of European ancestries, but these results do not reflect the global population or replicate well in non-European populations. Additionally, investigating traits at the proteome level may provide more insight to biological mechanisms than at the genome level. Using data from the TOPMed consortium, we have built protein models to perform PWAS using S-PrediXcan in published multiethnic GWAS data from the PAGE study (Wojcik et al 2019). This output reveals significant associations between genes and a variety of complex traits in non-European populations.

AB - Most GWAS have been conducted in populations of European ancestries, but these results do not reflect the global population or replicate well in non-European populations. Additionally, investigating traits at the proteome level may provide more insight to biological mechanisms than at the genome level. Using data from the TOPMed consortium, we have built protein models to perform PWAS using S-PrediXcan in published multiethnic GWAS data from the PAGE study (Wojcik et al 2019). This output reveals significant associations between genes and a variety of complex traits in non-European populations.

UR - https://ecommons.luc.edu/ures/2021/2021/126

M3 - Article

JO - Undergraduate Research and Engagement Symposium

JF - Undergraduate Research and Engagement Symposium

ER -

Proteome Association Studies in Populations of Diverse Ancestries

Abstract

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