Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program

TOPMed Lung Working Group

doi:10.1016/j.ajhg.2022.03.007

Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program

TOPMed Lung Working Group

University of Virginia School of Medicine
Brigham and Women's Hospital
Columbia University Medical Center
University of Colorado School of Medicine
University of Washington
University of Washington School of Medicine
Ann & Robert H. Lurie Children's Hospital of Chicago
Northwestern University Feinberg School of Medicine
University of Arizona College of Medicine – Tucson
University of Texas Health Science Center at Houston
Harvard Medical School
Johns Hopkins University
Baylor College of Medicine
Broad Institute
Boston University School of Public Health
University of North Carolina at Chapel Hill
Lundquist Institute at Harbor-UCLA Medical Center
The University of Texas Health Science Center
NHLBI Framingham Heart Study
Boston University
Boston University School of Medicine
Albert Einstein College of Medicine
Fred Hutchinson Cancer Center
Wake Forest University School of Medicine
National Institute of Health
New York Genome Center
Teachers College–Columbia University
Loyola University of Chicago
University of Chicago

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	857-870
Number of pages	14
Journal	American Journal of Human Genetics
Volume	109
Issue number	5
DOIs	https://doi.org/10.1016/j.ajhg.2022.03.007
State	Published - May 5 2022
Externally published	Yes

ASJC Scopus Subject Areas

Genetics
Genetics(clinical)

Keywords

cross-ethnic portability
gene expression
integrative analysis
polygenic transcriptome risk score
pulmonary disease
risk prediction

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10.1016/j.ajhg.2022.03.007

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@article{69c343a3daa64eb89dcf45e7f86fbccd,

title = "Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program",

keywords = "cross-ethnic portability, gene expression, integrative analysis, polygenic transcriptome risk score, pulmonary disease, risk prediction",

author = "\{TOPMed Lung Working Group\} and Xiaowei Hu and Dandi Qiao and Wonji Kim and Matthew Moll and Balte, \{Pallavi P.\} and Lange, \{Leslie A.\} and Bartz, \{Traci M.\} and Rajesh Kumar and Xingnan Li and Bing Yu and Cade, \{Brian E.\} and Laurie, \{Cecelia A.\} and Tamar Sofer and Ingo Ruczinski and Nickerson, \{Deborah A.\} and Muzny, \{Donna M.\} and Metcalf, \{Ginger A.\} and Harshavardhan Doddapaneni and Stacy Gabriel and Namrata Gupta and Shannon Dugan-Perez and Cupples, \{L. Adrienne\} and Loehr, \{Laura R.\} and Deepti Jain and Rotter, \{Jerome I.\} and Wilson, \{James G.\} and Psaty, \{Bruce M.\} and Myriam Fornage and Morrison, \{Alanna C.\} and Vasan, \{Ramachandran S.\} and George Washko and Rich, \{Stephen S.\} and O'Connor, \{George T.\} and Eugene Bleecker and Kaplan, \{Robert C.\} and Ravi Kalhan and Susan Redline and Gharib, \{Sina A.\} and Deborah Meyers and Victor Ortega and Jos{\'e}e Dupuis and London, \{Stephanie J.\} and Tuuli Lappalainen and Oelsner, \{Elizabeth C.\} and Silverman, \{Edwin K.\} and Barr, \{R. Graham\} and Thornton, \{Timothy A.\} and Wheeler, \{Heather E.\} and Cho, \{Michael H.\} and Im, \{Hae Kyung\}",

note = "Publisher Copyright: {\textcopyright} 2022 American Society of Human Genetics",

year = "2022",

month = may,

day = "5",

doi = "10.1016/j.ajhg.2022.03.007",

language = "English",

volume = "109",

pages = "857--870",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

number = "5",

}

TY - JOUR

T1 - Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program

AU - TOPMed Lung Working Group

AU - Hu, Xiaowei

AU - Qiao, Dandi

AU - Kim, Wonji

AU - Moll, Matthew

AU - Balte, Pallavi P.

AU - Lange, Leslie A.

AU - Bartz, Traci M.

AU - Kumar, Rajesh

AU - Li, Xingnan

AU - Yu, Bing

AU - Cade, Brian E.

AU - Laurie, Cecelia A.

AU - Sofer, Tamar

AU - Ruczinski, Ingo

AU - Nickerson, Deborah A.

AU - Muzny, Donna M.

AU - Metcalf, Ginger A.

AU - Doddapaneni, Harshavardhan

AU - Gabriel, Stacy

AU - Gupta, Namrata

AU - Dugan-Perez, Shannon

AU - Cupples, L. Adrienne

AU - Loehr, Laura R.

AU - Jain, Deepti

AU - Rotter, Jerome I.

AU - Wilson, James G.

AU - Psaty, Bruce M.

AU - Fornage, Myriam

AU - Morrison, Alanna C.

AU - Vasan, Ramachandran S.

AU - Washko, George

AU - Rich, Stephen S.

AU - O'Connor, George T.

AU - Bleecker, Eugene

AU - Kaplan, Robert C.

AU - Kalhan, Ravi

AU - Redline, Susan

AU - Gharib, Sina A.

AU - Meyers, Deborah

AU - Ortega, Victor

AU - Dupuis, Josée

AU - London, Stephanie J.

AU - Lappalainen, Tuuli

AU - Oelsner, Elizabeth C.

AU - Silverman, Edwin K.

AU - Barr, R. Graham

AU - Thornton, Timothy A.

AU - Wheeler, Heather E.

AU - Cho, Michael H.

AU - Im, Hae Kyung

PY - 2022/5/5

Y1 - 2022/5/5

KW - cross-ethnic portability

KW - gene expression

KW - integrative analysis

KW - polygenic transcriptome risk score

KW - pulmonary disease

KW - risk prediction

UR - https://www.scopus.com/pages/publications/85129668045

UR - https://www.scopus.com/pages/publications/85129668045#tab=citedBy

U2 - 10.1016/j.ajhg.2022.03.007

DO - 10.1016/j.ajhg.2022.03.007

M3 - Article

C2 - 35385699

AN - SCOPUS:85129668045

SN - 0002-9297

VL - 109

SP - 857

EP - 870

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 5

ER -

Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program

ASJC Scopus Subject Areas

Keywords

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