New (Nor)Aza-Adamantanes Are Agonists at the Newly Identified Serotonin 5HT4 Receptor and Antagonists at the 5HT3 Receptor

Daniel L. Flynn; Daniel Becker; Dale P. Spangler; Roger Nosal

doi:10.1016/S0960-894X(00)80441-2

New (Nor)Aza-Adamantanes Are Agonists at the Newly Identified Serotonin 5HT4 Receptor and Antagonists at the 5HT3 Receptor

Daniel L. Flynn, Daniel Becker, Dale P. Spangler, Roger Nosal

Department of Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

New aza(nor)adamantanes 1A, 1B, and 1C are described which exhibit properties of both 5-HT4 agonism and 5-HT3 antagonism. In particular, compound 1C [SC-52491], an azanoradamantane, exhibits an EC50 of 51 nM in a functional model of 5-HT4 agonism and potent antagonism, Ki = 1.2 nM, at the 5-HT3receptor.

Original language	American English
Journal	Chemistry: Faculty Publications and Other Works
Volume	2
Issue number	12
DOIs	https://doi.org/10.1016/S0960-894X(00)80441-2
State	Published - Dec 1 1992

Keywords

aza(nor)adamantanes

Disciplines

Chemistry

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title = "New (Nor)Aza-Adamantanes Are Agonists at the Newly Identified Serotonin 5HT4 Receptor and Antagonists at the 5HT3 Receptor",

abstract = " New aza(nor)adamantanes 1A, 1B, and 1C are described which exhibit properties of both 5-HT4 agonism and 5-HT3 antagonism. In particular, compound 1C [SC-52491], an azanoradamantane, exhibits an EC50 of 51 nM in a functional model of 5-HT4 agonism and potent antagonism, Ki = 1.2 nM, at the 5-HT3receptor.",

keywords = "aza(nor)adamantanes",

author = "Flynn, {Daniel L.} and Daniel Becker and Spangler, {Dale P.} and Roger Nosal",

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T1 - New (Nor)Aza-Adamantanes Are Agonists at the Newly Identified Serotonin 5HT4 Receptor and Antagonists at the 5HT3 Receptor

AU - Flynn, Daniel L.

AU - Becker, Daniel

AU - Spangler, Dale P.

AU - Nosal, Roger

PY - 1992/12/1

Y1 - 1992/12/1

N2 - New aza(nor)adamantanes 1A, 1B, and 1C are described which exhibit properties of both 5-HT4 agonism and 5-HT3 antagonism. In particular, compound 1C [SC-52491], an azanoradamantane, exhibits an EC50 of 51 nM in a functional model of 5-HT4 agonism and potent antagonism, Ki = 1.2 nM, at the 5-HT3receptor.

AB - New aza(nor)adamantanes 1A, 1B, and 1C are described which exhibit properties of both 5-HT4 agonism and 5-HT3 antagonism. In particular, compound 1C [SC-52491], an azanoradamantane, exhibits an EC50 of 51 nM in a functional model of 5-HT4 agonism and potent antagonism, Ki = 1.2 nM, at the 5-HT3receptor.

KW - aza(nor)adamantanes

UR - https://ecommons.luc.edu/chemistry_facpubs/8

U2 - 10.1016/S0960-894X(00)80441-2

DO - 10.1016/S0960-894X(00)80441-2

M3 - Article

VL - 2

JO - Chemistry: Faculty Publications and Other Works

JF - Chemistry: Faculty Publications and Other Works

IS - 12

ER -

New (Nor)Aza-Adamantanes Are Agonists at the Newly Identified Serotonin 5HT4 Receptor and Antagonists at the 5HT3 Receptor

Abstract

Keywords

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