Modifying the β,γ leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of dna polymerase β

Christopher A. Sucato; Thomas G. Upton; Boris A. Kashemirov; Vinod K. Batra; Václav Martínek; Yun Xiang; William A. Beard; Lars C. Pedersen; Samuel H. Wilson; Charles E. McKenna; Jan Florián; Arieh Warshel; Myron F. Goodman

doi:10.1021/bi061517b

Modifying the β,γ leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of dna polymerase β

Christopher A. Sucato
, Thomas G. Upton
, Boris A. Kashemirov
, Vinod K. Batra
, Václav Martínek
, Yun Xiang
, William A. Beard
, Lars C. Pedersen
, Samuel H. Wilson
, Charles E. McKenna
, Jan Florián
, Arieh Warshel
, Myron F. Goodman

University of Southern California
National Institute of Health
Loyola University of Chicago
Charles University

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	461-471
Number of pages	11
Journal	Physics Faculty Research and Publications
Volume	46
Issue number	2
DOIs	https://doi.org/10.1021/bi061517b
State	Published - Jan 16 2007
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry

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10.1021/bi061517b

Cite this

Sucato, C. A., Upton, T. G., Kashemirov, B. A., Batra, V. K., Martínek, V., Xiang, Y., Beard, W. A., Pedersen, L. C., Wilson, S. H., McKenna, C. E., Florián, J., Warshel, A., & Goodman, M. F. (2007). Modifying the β,γ leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of dna polymerase β. Physics Faculty Research and Publications, 46(2), 461-471. https://doi.org/10.1021/bi061517b

Modifying the β,γ leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of dna polymerase β. / Sucato, Christopher A.; Upton, Thomas G.; Kashemirov, Boris A. et al.
In: Physics Faculty Research and Publications, Vol. 46, No. 2, 16.01.2007, p. 461-471.

Research output: Contribution to journal › Article › peer-review

Sucato, CA, Upton, TG, Kashemirov, BA, Batra, VK, Martínek, V, Xiang, Y, Beard, WA, Pedersen, LC, Wilson, SH, McKenna, CE, Florián, J, Warshel, A & Goodman, MF 2007, 'Modifying the β,γ leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of dna polymerase β', Physics Faculty Research and Publications, vol. 46, no. 2, pp. 461-471. https://doi.org/10.1021/bi061517b

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title = "Modifying the β,γ leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of dna polymerase β",

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AU - Martínek, Václav

AU - Xiang, Yun

AU - Beard, William A.

AU - Pedersen, Lars C.

AU - Wilson, Samuel H.

AU - McKenna, Charles E.

AU - Florián, Jan

AU - Warshel, Arieh

AU - Goodman, Myron F.

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Modifying the β,γ leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of dna polymerase β

ASJC Scopus Subject Areas

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