MMP-13 Selective Isonipecotamide Alpha-sulfone Hydroxamates

Stephen A. Kolodziej; Susan L. Hockerman; Gary A. DeCrescenzo; Joseph J. McDonald; Grace E. Munie; Theresa R. Fletcher; Nathan Stehle; Craig Swearingen; Daniel Becker

doi:10.1016/j.bmcl.2010.04.111

MMP-13 Selective Isonipecotamide Alpha-sulfone Hydroxamates

Stephen A. Kolodziej
, Susan L. Hockerman
, Gary A. DeCrescenzo
, Joseph J. McDonald
, Grace E. Munie
, Theresa R. Fletcher
, Nathan Stehle
, Craig Swearingen
, Daniel Becker

Department of Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.

Original language	American English
Journal	Chemistry: Faculty Publications and Other Works
Volume	20
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2010.04.111
State	Published - Jun 15 2010

Keywords

hydroxamates
isonipecotamide

Disciplines

Chemistry

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Cite this

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title = "MMP-13 Selective Isonipecotamide Alpha-sulfone Hydroxamates",

abstract = " A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.",

keywords = "hydroxamates, isonipecotamide",

author = "Kolodziej, \{Stephen A.\} and Hockerman, \{Susan L.\} and DeCrescenzo, \{Gary A.\} and McDonald, \{Joseph J.\} and Munie, \{Grace E.\} and Fletcher, \{Theresa R.\} and Nathan Stehle and Craig Swearingen and Daniel Becker",

year = "2010",

month = jun,

day = "15",

doi = "10.1016/j.bmcl.2010.04.111",

language = "American English",

volume = "20",

journal = "Chemistry: Faculty Publications and Other Works",

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TY - JOUR

T1 - MMP-13 Selective Isonipecotamide Alpha-sulfone Hydroxamates

AU - Kolodziej, Stephen A.

AU - Hockerman, Susan L.

AU - DeCrescenzo, Gary A.

AU - McDonald, Joseph J.

AU - Munie, Grace E.

AU - Fletcher, Theresa R.

AU - Stehle, Nathan

AU - Swearingen, Craig

AU - Becker, Daniel

PY - 2010/6/15

Y1 - 2010/6/15

N2 - A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.

AB - A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.

KW - hydroxamates

KW - isonipecotamide

UR - https://ecommons.luc.edu/chemistry_facpubs/31

U2 - 10.1016/j.bmcl.2010.04.111

DO - 10.1016/j.bmcl.2010.04.111

M3 - Article

VL - 20

JO - Chemistry: Faculty Publications and Other Works

JF - Chemistry: Faculty Publications and Other Works

IS - 12

ER -

MMP-13 Selective Isonipecotamide Alpha-sulfone Hydroxamates

Abstract

Keywords

Disciplines

Access to Document

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