MMP-13 Selective Isonipecotamide Alpha-sulfone Hydroxamates

Stephen A. Kolodziej; Susan L. Hockerman; Gary A. DeCrescenzo; Joseph J. McDonald; Grace E. Munie; Theresa R. Fletcher; Nathan Stehle; Craig Swearingen; Daniel Becker

doi:10.1016/j.bmcl.2010.04.111

MMP-13 Selective Isonipecotamide Alpha-sulfone Hydroxamates

Stephen A. Kolodziej, Susan L. Hockerman, Gary A. DeCrescenzo, Joseph J. McDonald, Grace E. Munie, Theresa R. Fletcher, Nathan Stehle, Craig Swearingen, Daniel Becker

Department of Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.

Original language	American English
Journal	Chemistry: Faculty Publications and Other Works
Volume	20
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2010.04.111
State	Published - Jun 15 2010

Keywords

hydroxamates
isonipecotamide

Disciplines

Chemistry

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title = "MMP-13 Selective Isonipecotamide Alpha-sulfone Hydroxamates",

abstract = " A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.",

keywords = "hydroxamates, isonipecotamide",

author = "Kolodziej, {Stephen A.} and Hockerman, {Susan L.} and DeCrescenzo, {Gary A.} and McDonald, {Joseph J.} and Munie, {Grace E.} and Fletcher, {Theresa R.} and Nathan Stehle and Craig Swearingen and Daniel Becker",

year = "2010",

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doi = "10.1016/j.bmcl.2010.04.111",

language = "American English",

volume = "20",

journal = "Chemistry: Faculty Publications and Other Works",

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T1 - MMP-13 Selective Isonipecotamide Alpha-sulfone Hydroxamates

AU - Kolodziej, Stephen A.

AU - Hockerman, Susan L.

AU - DeCrescenzo, Gary A.

AU - McDonald, Joseph J.

AU - Munie, Grace E.

AU - Fletcher, Theresa R.

AU - Stehle, Nathan

AU - Swearingen, Craig

AU - Becker, Daniel

PY - 2010/6/15

Y1 - 2010/6/15

N2 - A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.

AB - A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.

KW - hydroxamates

KW - isonipecotamide

UR - https://ecommons.luc.edu/chemistry_facpubs/31

U2 - 10.1016/j.bmcl.2010.04.111

DO - 10.1016/j.bmcl.2010.04.111

M3 - Article

VL - 20

JO - Chemistry: Faculty Publications and Other Works

JF - Chemistry: Faculty Publications and Other Works

IS - 12

ER -

MMP-13 Selective Isonipecotamide Alpha-sulfone Hydroxamates

Abstract

Keywords

Disciplines

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