MMP-13 Selective Alpha-sulfone Hydroxamates: Identification of Selective P1' Amides

Yvette M. Fobian; John N. Freskos; Thomas E. Barta; Louis J. Bedell; Daniel Becker

doi:10.1016/j.bmcl.2011.03.095

MMP-13 Selective Alpha-sulfone Hydroxamates: Identification of Selective P1' Amides

Yvette M. Fobian, John N. Freskos, Thomas E. Barta, Louis J. Bedell, Daniel Becker

Department of Chemistry and Biochemistry

Pfizer Research & Development

Research output: Contribution to journal › Article › peer-review

Abstract

Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.

Original language	American English
Journal	Chemistry: Faculty Publications and Other Works
Volume	21
Issue number	10
DOIs	https://doi.org/10.1016/j.bmcl.2011.03.095
State	Published - May 15 2011

Keywords

MMP-13
hydroxamates
P1’ amides

Disciplines

Chemistry

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title = "MMP-13 Selective Alpha-sulfone Hydroxamates: Identification of Selective P1' Amides",

abstract = " Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.",

keywords = "MMP-13, hydroxamates, P1{\textquoteright} amides",

author = "Fobian, {Yvette M.} and Freskos, {John N.} and Barta, {Thomas E.} and Bedell, {Louis J.} and Daniel Becker",

year = "2011",

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language = "American English",

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AU - Fobian, Yvette M.

AU - Freskos, John N.

AU - Barta, Thomas E.

AU - Bedell, Louis J.

AU - Becker, Daniel

PY - 2011/5/15

Y1 - 2011/5/15

N2 - Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.

AB - Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.

KW - MMP-13

KW - hydroxamates

KW - P1’ amides

UR - https://ecommons.luc.edu/chemistry_facpubs/36

U2 - 10.1016/j.bmcl.2011.03.095

DO - 10.1016/j.bmcl.2011.03.095

M3 - Article

VL - 21

JO - Chemistry: Faculty Publications and Other Works

JF - Chemistry: Faculty Publications and Other Works

IS - 10

ER -

MMP-13 Selective Alpha-sulfone Hydroxamates: Identification of Selective P1' Amides

Abstract

Keywords

Disciplines

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