Mechanismof Inactivation of Ornithine Aminotransferaseby (1 S ,3 S )‑3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylicAcid

Matthew J. Moschitto; Peter F. Doubleday; Daniel S. Catlin; Neil L. Kelleher; Dali Liu; Richard B. Silverman

doi:10.1021/jacs.9b03254

Mechanismof Inactivation of Ornithine Aminotransferaseby (1 S ,3 S )‑3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylicAcid

Matthew J. Moschitto
, Peter F. Doubleday
, Daniel S. Catlin
, Neil L. Kelleher
, Dali Liu
, Richard B. Silverman

Department of Chemistry and Biochemistry

Loyola University Chicago

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of the American Chemical Society
Volume	141
Issue number	27
DOIs	https://doi.org/10.1021/jacs.9b03254
State	Published - Jul 10 2019

Disciplines

Pharmacology
Organic Chemistry

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@article{60f5a4ab7a3f443dafb97136ec4e2d92,

title = "Mechanismof Inactivation of Ornithine Aminotransferaseby (1 S ,3 S )‑3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylicAcid",

author = "Moschitto, \{Matthew J.\} and Doubleday, \{Peter F.\} and Catlin, \{Daniel S.\} and Kelleher, \{Neil L.\} and Dali Liu and Silverman, \{Richard B.\}",

note = "The inhibition of ornithine aminotransferase (OAT), a pyridoxal 5′-phosphate-dependent enzyme, has been implicated as a treatment for hepatocellular carcinoma (HCC), the most common form of liver cancer, for which there is no effective treatment.",

year = "2019",

month = jul,

day = "10",

doi = "10.1021/jacs.9b03254",

language = "American English",

volume = "141",

journal = "Journal of the American Chemical Society",

number = "27",

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TY - JOUR

T1 - Mechanismof Inactivation of Ornithine Aminotransferaseby (1 S ,3 S )‑3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylicAcid

AU - Moschitto, Matthew J.

AU - Doubleday, Peter F.

AU - Catlin, Daniel S.

AU - Kelleher, Neil L.

AU - Liu, Dali

AU - Silverman, Richard B.

N1 - The inhibition of ornithine aminotransferase (OAT), a pyridoxal 5′-phosphate-dependent enzyme, has been implicated as a treatment for hepatocellular carcinoma (HCC), the most common form of liver cancer, for which there is no effective treatment.

PY - 2019/7/10

Y1 - 2019/7/10

UR - https://pubs.acs.org/doi/10.1021/jacs.9b03254

U2 - 10.1021/jacs.9b03254

DO - 10.1021/jacs.9b03254

M3 - Article

VL - 141

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 27

ER -

Mechanismof Inactivation of Ornithine Aminotransferaseby (1 S ,3 S )‑3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylicAcid

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