Inhibition of SIRT2 suppresses hepatic fibrosis

Maribel Arteaga; Na Shang; Xianzhong Ding; Sherri Yong; Scott J. Cotler; Mitchell F. Denning; Takashi Shimamura; Peter Breslin; Bernhard Lüscher; Wei Qiu

doi:10.1152/ajpgi.00271.2015

Inhibition of SIRT2 suppresses hepatic fibrosis

Maribel Arteaga, Na Shang, Xianzhong Ding, Sherri Yong, Scott J. Cotler, Mitchell F. Denning, Takashi Shimamura, Peter Breslin, Bernhard Lüscher, Wei Qiu

Department of Biology

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	American Journal of Physiology-gastrointestinal and Liver Physiology
Volume	310
Issue number	11
DOIs	https://doi.org/10.1152/ajpgi.00271.2015
State	Published - Jun 1 2016

Disciplines

Biochemistry
Biology

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10.1152/ajpgi.00271.2015License: Unspecified

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@article{42ba2e98fe034112b8a9c68dd14734b2,

title = "Inhibition of SIRT2 suppresses hepatic fibrosis",

author = "Maribel Arteaga and Na Shang and Xianzhong Ding and Sherri Yong and Cotler, {Scott J.} and Denning, {Mitchell F.} and Takashi Shimamura and Peter Breslin and Bernhard L{\"u}scher and Wei Qiu",

note = "In conclusion, our results show that SIRT2 promotes hepatic fibrogenesis by regulating the ERK/c-MYC pathway. Inhibition of SIRT2 may represent a novel and effective strategy to protect against the development of hepatic fibrosis.",

year = "2016",

month = jun,

day = "1",

doi = "10.1152/ajpgi.00271.2015",

language = "American English",

volume = "310",

journal = "American Journal of Physiology-gastrointestinal and Liver Physiology",

issn = "1522-1547",

number = "11",

}

TY - JOUR

T1 - Inhibition of SIRT2 suppresses hepatic fibrosis

AU - Arteaga, Maribel

AU - Shang, Na

AU - Ding, Xianzhong

AU - Yong, Sherri

AU - Cotler, Scott J.

AU - Denning, Mitchell F.

AU - Shimamura, Takashi

AU - Breslin, Peter

AU - Lüscher, Bernhard

AU - Qiu, Wei

N1 - In conclusion, our results show that SIRT2 promotes hepatic fibrogenesis by regulating the ERK/c-MYC pathway. Inhibition of SIRT2 may represent a novel and effective strategy to protect against the development of hepatic fibrosis.

PY - 2016/6/1

Y1 - 2016/6/1

UR - https://www.physiology.org/doi/full/10.1152/ajpgi.00271.2015

U2 - 10.1152/ajpgi.00271.2015

DO - 10.1152/ajpgi.00271.2015

M3 - Article

SN - 1522-1547

VL - 310

JO - American Journal of Physiology-gastrointestinal and Liver Physiology

JF - American Journal of Physiology-gastrointestinal and Liver Physiology

IS - 11

ER -

Inhibition of SIRT2 suppresses hepatic fibrosis

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