Genetic and environmental variation impact transferability of polygenic risk scores

Daniel S. Araújo; Heather E. Wheeler

doi:10.1016/j.xcrm.2022.100687

Genetic and environmental variation impact transferability of polygenic risk scores

Daniel S. Araújo, Heather E. Wheeler

Department of Biology

Loyola University Chicago

Research output: Contribution to journal › Article › peer-review

Abstract

Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk assessment.

Original language	American English
Journal	History: Faculty Publications and Other Works
Volume	3
Issue number	7
DOIs	https://doi.org/10.1016/j.xcrm.2022.100687
State	Published - Jul 19 2022

Keywords

polygenic risk scores
genetic variation
genome-wide association studies

Disciplines

Biology

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Cite this

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title = "Genetic and environmental variation impact transferability of polygenic risk scores",

abstract = " Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk assessment.",

keywords = "polygenic risk scores, genetic variation, genome-wide association studies",

author = "Ara{\'u}jo, {Daniel S.} and Wheeler, {Heather E.}",

year = "2022",

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language = "American English",

volume = "3",

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T1 - Genetic and environmental variation impact transferability of polygenic risk scores

AU - Araújo, Daniel S.

AU - Wheeler, Heather E.

PY - 2022/7/19

Y1 - 2022/7/19

N2 - Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk assessment.

AB - Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk assessment.

KW - polygenic risk scores

KW - genetic variation

KW - genome-wide association studies

UR - https://ecommons.luc.edu/biology_facpubs/186

U2 - 10.1016/j.xcrm.2022.100687

DO - 10.1016/j.xcrm.2022.100687

M3 - Article

VL - 3

JO - History: Faculty Publications and Other Works

JF - History: Faculty Publications and Other Works

IS - 7

ER -

Genetic and environmental variation impact transferability of polygenic risk scores

Abstract

Keywords

Disciplines

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