Gene networks that compensate for crosstalk with crosstalk

Isaak E. Müller; Jacob R. Rubens; Tomi Jun; Tomi Jun; Daniel Graham; Daniel Graham; Ramnik Xavier; Ramnik Xavier; Timothy K. Lu

doi:10.1038/s41467-019-12021-y

Gene networks that compensate for crosstalk with crosstalk

Isaak E. Müller, Jacob R. Rubens, Tomi Jun, Tomi Jun, Daniel Graham, Daniel Graham, Ramnik Xavier, Ramnik Xavier, Timothy K. Lu

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Nature Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-12021-y
State	Published - Dec 1 2019
Externally published	Yes

Disciplines

Biology
Computational Biology
Genetics

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10.1038/s41467-019-12021-yLicense: Unspecified

Cite this

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title = "Gene networks that compensate for crosstalk with crosstalk",

author = "M{\"u}ller, {Isaak E.} and Rubens, {Jacob R.} and Tomi Jun and Tomi Jun and Daniel Graham and Daniel Graham and Ramnik Xavier and Ramnik Xavier and Lu, {Timothy K.}",

note = "Crosstalk is a major challenge to engineering sophisticated synthetic gene networks. A common approach is to insulate signal-transduction pathways by minimizing molecular-level crosstalk between endogenous and synthetic genetic components, but this strategy can be difficult to apply in the context of complex, natural gene networks and unknown interactions.",

year = "2019",

month = dec,

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doi = "10.1038/s41467-019-12021-y",

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volume = "10",

journal = "Nature Communications",

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T1 - Gene networks that compensate for crosstalk with crosstalk

AU - Müller, Isaak E.

AU - Rubens, Jacob R.

AU - Jun, Tomi

AU - Graham, Daniel

AU - Xavier, Ramnik

AU - Lu, Timothy K.

N1 - Crosstalk is a major challenge to engineering sophisticated synthetic gene networks. A common approach is to insulate signal-transduction pathways by minimizing molecular-level crosstalk between endogenous and synthetic genetic components, but this strategy can be difficult to apply in the context of complex, natural gene networks and unknown interactions.

PY - 2019/12/1

Y1 - 2019/12/1

UR - https://www.nature.com/articles/s41467-019-12021-y

U2 - 10.1038/s41467-019-12021-y

DO - 10.1038/s41467-019-12021-y

M3 - Article

SN - 2041-1723

VL - 10

JO - Nature Communications

JF - Nature Communications

IS - 1

ER -

Gene networks that compensate for crosstalk with crosstalk

Disciplines

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