Evidence for two distinct Mg2+ binding sites in Gsα and Giα1 proteins

Christopher S. Malarkey; Guoyan Wang; Miguel A. Ballicora; Duarte E. Mota de Freitas

doi:10.1016/j.bbrc.2008.05.158

Evidence for two distinct Mg2+ binding sites in Gsα and Giα1 proteins

Christopher S. Malarkey, Guoyan Wang, Miguel A. Ballicora, Duarte E. Mota de Freitas

Department of Chemistry and Biochemistry

Loyola University Chicago

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Biochemical and Biophysical Research Communications
Volume	372
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2008.05.158
State	Published - Jan 8 2008

Disciplines

Molecular Biology
Biochemistry

Access to Document

10.1016/j.bbrc.2008.05.158License: Unspecified

Cite this

@article{0a5752392e824abaadc4cfbbf21ad569,

title = "Evidence for two distinct Mg2+ binding sites in Gsα and Giα1 proteins",

author = "Malarkey, {Christopher S.} and Guoyan Wang and Ballicora, {Miguel A.} and {de Freitas}, {Duarte E. Mota}",

note = "The function of guanine nucleotide binding (G) proteins is Mg 2+ dependent with guanine nucleotide exchange requiring higher metal ion concentration than guanosine 5′-triphosphate hydrolysis. It is unclear whether two Mg 2+ binding sites are present or if one Mg 2+ binding site exhibits different affinities for the inactive GDP-bound or the active GTP-bound conformations.",

year = "2008",

month = jan,

day = "8",

doi = "10.1016/j.bbrc.2008.05.158",

language = "American English",

volume = "372",

journal = "Biochemical and Biophysical Research Communications",

number = "4",

}

TY - JOUR

T1 - Evidence for two distinct Mg2+ binding sites in Gsα and Giα1 proteins

AU - Malarkey, Christopher S.

AU - Wang, Guoyan

AU - Ballicora, Miguel A.

AU - de Freitas, Duarte E. Mota

N1 - The function of guanine nucleotide binding (G) proteins is Mg 2+ dependent with guanine nucleotide exchange requiring higher metal ion concentration than guanosine 5′-triphosphate hydrolysis. It is unclear whether two Mg 2+ binding sites are present or if one Mg 2+ binding site exhibits different affinities for the inactive GDP-bound or the active GTP-bound conformations.

PY - 2008/1/8

Y1 - 2008/1/8

UR - https://www.sciencedirect.com/science/article/pii/S0006291X08010723

U2 - 10.1016/j.bbrc.2008.05.158

DO - 10.1016/j.bbrc.2008.05.158

M3 - Article

VL - 372

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Evidence for two distinct Mg2+ binding sites in Gsα and Giα1 proteins

Disciplines

Access to Document

Other files and links

Cite this