Evidence for two distinct Mg 2+ binding sites in G sa and G ia1 proteins

TY - JOUR

T1 - Evidence for two distinct Mg 2+ binding sites in G sa and G ia1 proteins

AU - Malarkey, Christopher S.

AU - Wang, Guo-yan

AU - Ballicora, Miguel A.

AU - de Freitas, Duarte Mota

N1 - The function of guanine nucleotide binding (G) proteins is Mg 2+ dependent with guanine nucleotide exchange requiring higher metal ion concentration than guanosine 5′-triphosphate hydrolysis. It is unclear whether two Mg 2+ binding sites are present or if one Mg 2+ binding site exhibits different affinities for the inactive GDP-bound or the active GTP-bound conformations.

PY - 2008/1/1

Y1 - 2008/1/1

UR - http://www.sciencedirect.com/science/article/pii/S0006291X08010723

M3 - Article

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

ER -