DNA polymerase β catalytic efficiency mirrors the Asn279–dCTP H-bonding strength

Václav Martínek; Urban Bren; Myron F. Goodman; Arieh Warshel; Jan Florián; Jan Florian

doi:10.1016/j.febslet.2007.01.042

DNA polymerase β catalytic efficiency mirrors the Asn279–dCTP H-bonding strength

Václav Martínek, Urban Bren, Myron F. Goodman, Arieh Warshel, Jan Florián, Jan Florian

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	FEBS Letters
Volume	581
Issue number	4
DOIs	https://doi.org/10.1016/j.febslet.2007.01.042
State	Published - Feb 20 2007

Disciplines

Molecular Biology
Biochemistry

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@article{eda02a4780fb4991a85275705bd58e33,

title = "DNA polymerase β catalytic efficiency mirrors the Asn279–dCTP H-bonding strength",

author = "V{\'a}clav Mart{\'i}nek and Urban Bren and Goodman, {Myron F.} and Arieh Warshel and Jan Flori{\'a}n and Jan Florian",

note = "Ternary complexes of wild type or mutant form of human DNA polymerase β (pol β) bound to DNA and dCTP substrates were studied by molecular dynamics (MD) simulations. The occurrences of contact configurations (CC) of structurally important atom pairs were sampled along the MD trajectories, and converted into free-energy differences, Δ G CC.",

year = "2007",

month = feb,

day = "20",

doi = "10.1016/j.febslet.2007.01.042",

language = "American English",

volume = "581",

journal = "FEBS Letters",

number = "4",

}

TY - JOUR

T1 - DNA polymerase β catalytic efficiency mirrors the Asn279–dCTP H-bonding strength

AU - Martínek, Václav

AU - Bren, Urban

AU - Goodman, Myron F.

AU - Warshel, Arieh

AU - Florián, Jan

AU - Florian, Jan

N1 - Ternary complexes of wild type or mutant form of human DNA polymerase β (pol β) bound to DNA and dCTP substrates were studied by molecular dynamics (MD) simulations. The occurrences of contact configurations (CC) of structurally important atom pairs were sampled along the MD trajectories, and converted into free-energy differences, Δ G CC.

PY - 2007/2/20

Y1 - 2007/2/20

UR - https://www.sciencedirect.com/science/article/pii/S0014579307000804

U2 - 10.1016/j.febslet.2007.01.042

DO - 10.1016/j.febslet.2007.01.042

M3 - Article

VL - 581

JO - FEBS Letters

JF - FEBS Letters

IS - 4

ER -

DNA polymerase β catalytic efficiency mirrors the Asn279–dCTP H-bonding strength

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