Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

Anthony Trimboli; Koichi Fukino; Alain De Bruin; Guo Wei; Lei Shen; Stephan M. Tanner; Nicholas Creasap; Thomas J. Rosol; Michael L. Robinson; Charis Eng; Michael C. Ostrowski; Gustavo Leone

doi:10.1158/0008-5472.CAN-07-2148

Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

Anthony Trimboli, Koichi Fukino, Alain De Bruin, Guo Wei, Lei Shen, Stephan M. Tanner, Nicholas Creasap, Thomas J. Rosol, Michael L. Robinson, Charis Eng, Michael C. Ostrowski, Gustavo Leone

Research output: Contribution to journal › Article › peer-review

Abstract

We developed stromal- and epithelial-specific cre-transgenic mice to directly visualize epithelial-mesenchymal transition (EMT) during cancer progression in vivo. Using three different oncogene-driven mouse mammary tumor models and cell-fate mapping strategies, we show in vivo evidence for the existence of EMT in breast cancer and show that myc can specifically elicit this process. Hierarchical cluster analysis of genome-wide loss of heterozygosity reveals that the incidence of EMT in invasive human breast carcinomas is rare, but when it occurs it is associated with the amplification of MYC. These data provide the first direct evidence for EMT in breast cancer and suggest that its development is favored by myc-initiated events.

Original language	American English
Journal	ETSU Faculty Works
Volume	68
Issue number	3
DOIs	https://doi.org/10.1158/0008-5472.CAN-07-2148
State	Published - Feb 1 2008
Externally published	Yes

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title = "Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer",

abstract = " We developed stromal- and epithelial-specific cre-transgenic mice to directly visualize epithelial-mesenchymal transition (EMT) during cancer progression in vivo. Using three different oncogene-driven mouse mammary tumor models and cell-fate mapping strategies, we show in vivo evidence for the existence of EMT in breast cancer and show that myc can specifically elicit this process. Hierarchical cluster analysis of genome-wide loss of heterozygosity reveals that the incidence of EMT in invasive human breast carcinomas is rare, but when it occurs it is associated with the amplification of MYC. These data provide the first direct evidence for EMT in breast cancer and suggest that its development is favored by myc-initiated events.",

author = "Anthony Trimboli and Koichi Fukino and {De Bruin}, Alain and Guo Wei and Lei Shen and Tanner, {Stephan M.} and Nicholas Creasap and Rosol, {Thomas J.} and Robinson, {Michael L.} and Charis Eng and Ostrowski, {Michael C.} and Gustavo Leone",

year = "2008",

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doi = "10.1158/0008-5472.CAN-07-2148",

language = "American English",

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TY - JOUR

T1 - Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

AU - Trimboli, Anthony

AU - Fukino, Koichi

AU - De Bruin, Alain

AU - Wei, Guo

AU - Shen, Lei

AU - Tanner, Stephan M.

AU - Creasap, Nicholas

AU - Rosol, Thomas J.

AU - Robinson, Michael L.

AU - Eng, Charis

AU - Ostrowski, Michael C.

AU - Leone, Gustavo

PY - 2008/2/1

Y1 - 2008/2/1

N2 - We developed stromal- and epithelial-specific cre-transgenic mice to directly visualize epithelial-mesenchymal transition (EMT) during cancer progression in vivo. Using three different oncogene-driven mouse mammary tumor models and cell-fate mapping strategies, we show in vivo evidence for the existence of EMT in breast cancer and show that myc can specifically elicit this process. Hierarchical cluster analysis of genome-wide loss of heterozygosity reveals that the incidence of EMT in invasive human breast carcinomas is rare, but when it occurs it is associated with the amplification of MYC. These data provide the first direct evidence for EMT in breast cancer and suggest that its development is favored by myc-initiated events.

AB - We developed stromal- and epithelial-specific cre-transgenic mice to directly visualize epithelial-mesenchymal transition (EMT) during cancer progression in vivo. Using three different oncogene-driven mouse mammary tumor models and cell-fate mapping strategies, we show in vivo evidence for the existence of EMT in breast cancer and show that myc can specifically elicit this process. Hierarchical cluster analysis of genome-wide loss of heterozygosity reveals that the incidence of EMT in invasive human breast carcinomas is rare, but when it occurs it is associated with the amplification of MYC. These data provide the first direct evidence for EMT in breast cancer and suggest that its development is favored by myc-initiated events.

UR - https://dc.etsu.edu/etsu-works/17416

UR - https://doi.org/10.1158/0008-5472.CAN-07-2148

U2 - 10.1158/0008-5472.CAN-07-2148

DO - 10.1158/0008-5472.CAN-07-2148

M3 - Article

SN - 0008-5472

VL - 68

JO - ETSU Faculty Works

JF - ETSU Faculty Works

IS - 3

ER -

Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

Abstract

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