Dihydropyrmidine dehydrogenase from Escherichia coli: Transient state analysis reveals both reductive activation prior to turnover and diminished substrate effector roles relative to the mammalian form

Tyler B. Alt; Matthew R. Hoag; Graham R. Moran

doi:10.1016/j.abb.2023.109772

Dihydropyrmidine dehydrogenase from Escherichia coli: Transient state analysis reveals both reductive activation prior to turnover and diminished substrate effector roles relative to the mammalian form

Tyler B. Alt, Matthew R. Hoag, Graham R. Moran

Loyola University of Chicago

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	109772
Journal	Archives of Biochemistry and Biophysics
Volume	748
DOIs	https://doi.org/10.1016/j.abb.2023.109772
State	Published - Oct 15 2023
Externally published	Yes

ASJC Scopus Subject Areas

Biophysics
Biochemistry
Molecular Biology

Access to Document

10.1016/j.abb.2023.109772

Cite this

Dihydropyrmidine dehydrogenase from Escherichia coli: Transient state analysis reveals both reductive activation prior to turnover and diminished substrate effector roles relative to the mammalian form. / Alt, Tyler B.; Hoag, Matthew R.; Moran, Graham R.
In: Archives of Biochemistry and Biophysics, Vol. 748, 109772, 15.10.2023.

Research output: Contribution to journal › Article › peer-review

@article{558a6c74bfa84abdb5e2a038fecba2c8,

title = "Dihydropyrmidine dehydrogenase from Escherichia coli: Transient state analysis reveals both reductive activation prior to turnover and diminished substrate effector roles relative to the mammalian form",

author = "Alt, {Tyler B.} and Hoag, {Matthew R.} and Moran, {Graham R.}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

month = oct,

day = "15",

doi = "10.1016/j.abb.2023.109772",

language = "English",

volume = "748",

journal = "Archives of Biochemistry and Biophysics",

issn = "0003-9861",

}

TY - JOUR

T1 - Dihydropyrmidine dehydrogenase from Escherichia coli

T2 - Transient state analysis reveals both reductive activation prior to turnover and diminished substrate effector roles relative to the mammalian form

AU - Alt, Tyler B.

AU - Hoag, Matthew R.

AU - Moran, Graham R.

PY - 2023/10/15

Y1 - 2023/10/15

UR - http://www.scopus.com/inward/record.url?scp=85173698189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85173698189&partnerID=8YFLogxK

U2 - 10.1016/j.abb.2023.109772

DO - 10.1016/j.abb.2023.109772

M3 - Article

C2 - 37820757

AN - SCOPUS:85173698189

SN - 0003-9861

VL - 748

JO - Archives of Biochemistry and Biophysics

JF - Archives of Biochemistry and Biophysics

M1 - 109772

ER -

Dihydropyrmidine dehydrogenase from Escherichia coli: Transient state analysis reveals both reductive activation prior to turnover and diminished substrate effector roles relative to the mammalian form

ASJC Scopus Subject Areas

Access to Document

Other files and links

Cite this