Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase

Allison N. Devitt; Abigail L. Vargas; Wei Zhu; Benjamin James Des Soye; Fatma Ayaloglu Butun; Tyler Alt; Nicholas Kaley; Glaucio M. Ferreira; Graham R. Moran; Neil L. Kelleher; Dali Liu; Richard B. Silverman

doi:10.1021/acschembio.4c00022

Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase

Allison N. Devitt
, Abigail L. Vargas
, Wei Zhu
, Benjamin James Des Soye
, Fatma Ayaloglu Butun
, Tyler Alt
, Nicholas Kaley
, Glaucio M. Ferreira
, Graham R. Moran
, Neil L. Kelleher
, Dali Liu
, Richard B. Silverman

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1066-1081
Number of pages	16
Journal	ACS Chemical Biology
Volume	19
Issue number	5
DOIs	https://doi.org/10.1021/acschembio.4c00022
State	Published - May 17 2024
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine

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10.1021/acschembio.4c00022

Cite this

Devitt, A. N., Vargas, A. L., Zhu, W., Des Soye, B. J., Butun, F. A., Alt, T., Kaley, N., Ferreira, G. M., Moran, G. R., Kelleher, N. L., Liu, D., & Silverman, R. B. (2024). Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. ACS Chemical Biology, 19(5), 1066-1081. https://doi.org/10.1021/acschembio.4c00022

Devitt, AN, Vargas, AL, Zhu, W, Des Soye, BJ, Butun, FA, Alt, T, Kaley, N, Ferreira, GM, Moran, GR, Kelleher, NL, Liu, D & Silverman, RB 2024, 'Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase', ACS Chemical Biology, vol. 19, no. 5, pp. 1066-1081. https://doi.org/10.1021/acschembio.4c00022

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AU - Devitt, Allison N.

AU - Vargas, Abigail L.

AU - Zhu, Wei

AU - Des Soye, Benjamin James

AU - Butun, Fatma Ayaloglu

AU - Alt, Tyler

AU - Kaley, Nicholas

AU - Ferreira, Glaucio M.

AU - Moran, Graham R.

AU - Kelleher, Neil L.

AU - Liu, Dali

AU - Silverman, Richard B.

PY - 2024/5/17

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Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase

ASJC Scopus Subject Areas

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