Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction

Jose I. Juncosa; Kenji Takaya; Hoang V. Le; Matthew J. Moschitto; Pathum M. Weerawarna; Romila Mascarenhas; Dali Liu; Stephen L. Dewey; Richard B. Silverman

doi:10.1021/jacs.7b10965

Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction

Jose I. Juncosa
, Kenji Takaya
, Hoang V. Le
, Matthew J. Moschitto
, Pathum M. Weerawarna
, Romila Mascarenhas
, Dali Liu
, Stephen L. Dewey
, Richard B. Silverman

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	2151-2164
Number of pages	14
Journal	Chemistry Faculty Research and Publications
Volume	140
Issue number	6
DOIs	https://doi.org/10.1021/jacs.7b10965
State	Published - Feb 14 2018
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/jacs.7b10965

Cite this

Juncosa, J. I., Takaya, K., Le, H. V., Moschitto, M. J., Weerawarna, P. M., Mascarenhas, R., Liu, D., Dewey, S. L., & Silverman, R. B. (2018). Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. Chemistry Faculty Research and Publications, 140(6), 2151-2164. https://doi.org/10.1021/jacs.7b10965

Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. / Juncosa, Jose I.; Takaya, Kenji; Le, Hoang V. et al.
In: Chemistry Faculty Research and Publications, Vol. 140, No. 6, 14.02.2018, p. 2151-2164.

Research output: Contribution to journal › Article › peer-review

Juncosa, JI, Takaya, K, Le, HV, Moschitto, MJ, Weerawarna, PM, Mascarenhas, R, Liu, D, Dewey, SL & Silverman, RB 2018, 'Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction', Chemistry Faculty Research and Publications, vol. 140, no. 6, pp. 2151-2164. https://doi.org/10.1021/jacs.7b10965

Juncosa JI, Takaya K, Le HV, Moschitto MJ, Weerawarna PM, Mascarenhas R et al. Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. Chemistry Faculty Research and Publications. 2018 Feb 14;140(6):2151-2164. doi: 10.1021/jacs.7b10965

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title = "Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction",

author = "Juncosa, \{Jose I.\} and Kenji Takaya and Le, \{Hoang V.\} and Moschitto, \{Matthew J.\} and Weerawarna, \{Pathum M.\} and Romila Mascarenhas and Dali Liu and Dewey, \{Stephen L.\} and Silverman, \{Richard B.\}",

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AU - Takaya, Kenji

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AU - Moschitto, Matthew J.

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AU - Dewey, Stephen L.

AU - Silverman, Richard B.

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Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction

ASJC Scopus Subject Areas

Access to Document

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