Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction

Jose I. Juncosa; Kenji Takaya; Hoang V. Le; Matthew J. Moschitto; Pathum M. Weerawarna; Romila Mascarenhas; Dali Liu; Stephen L. Dewey; Richard B. Silverman

doi:10.1021/jacs.7b10965

Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction

Jose I. Juncosa, Kenji Takaya, Hoang V. Le, Matthew J. Moschitto, Pathum M. Weerawarna, Romila Mascarenhas, Dali Liu, Stephen L. Dewey, Richard B. Silverman

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	2151-2164
Number of pages	14
Journal	Chemistry Faculty Research and Publications
Volume	140
Issue number	6
DOIs	https://doi.org/10.1021/jacs.7b10965
State	Published - Feb 14 2018
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/jacs.7b10965

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Juncosa, J. I., Takaya, K., Le, H. V., Moschitto, M. J., Weerawarna, P. M., Mascarenhas, R., Liu, D., Dewey, S. L., & Silverman, R. B. (2018). Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. Chemistry Faculty Research and Publications, 140(6), 2151-2164. https://doi.org/10.1021/jacs.7b10965

Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. / Juncosa, Jose I.; Takaya, Kenji; Le, Hoang V. et al.
In: Chemistry Faculty Research and Publications, Vol. 140, No. 6, 14.02.2018, p. 2151-2164.

Research output: Contribution to journal › Article › peer-review

Juncosa, JI, Takaya, K, Le, HV, Moschitto, MJ, Weerawarna, PM, Mascarenhas, R, Liu, D, Dewey, SL & Silverman, RB 2018, 'Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction', Chemistry Faculty Research and Publications, vol. 140, no. 6, pp. 2151-2164. https://doi.org/10.1021/jacs.7b10965

Juncosa JI, Takaya K, Le HV, Moschitto MJ, Weerawarna PM, Mascarenhas R et al. Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. Chemistry Faculty Research and Publications. 2018 Feb 14;140(6):2151-2164. doi: 10.1021/jacs.7b10965

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Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction

ASJC Scopus Subject Areas

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