TY - CHAP
T1 - Crosslinked and Polymerized Hemoglobins as Potential Blood Substitutes
AU - Olsen, Kenneth W.
AU - Tarasov, Eugene
PY - 2011/7/4
Y1 - 2011/7/4
KW - Crosslinked and polymerized hemoglobins - as potential blood substitutes
KW - Crosslinking Hb, logical step - in avoiding Hb extravasation into tissue
KW - Crosslinking tetramer before polymerization - stabilizing protein controlling oxygen affinity
KW - Double crosslinking of protein - Hb, crosslinking followed by PEGylation
KW - Hb octamer formation - using azide-alkyne click chemistry
KW - Hb polymers, large Hb oligomer development - using polymerization methods
KW - HBOC production, modification of hemoglobin (Hb) tetramer - properties for blood substitute
KW - Multilinker structures, and multilinking - three or more groups on Hb
KW - Multilinker success - and tetralinked Hb octamer production
KW - Polymerization, by sulfhydryl-maleimide click chemistry
UR - http://www.scopus.com/inward/record.url?scp=84885695779&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885695779&partnerID=8YFLogxK
U2 - 10.1002/9781119975427.ch24
DO - 10.1002/9781119975427.ch24
M3 - Chapter
AN - SCOPUS:84885695779
SN - 9780470686683
SP - 327
EP - 344
BT - Chemistry and Biochemistry of Oxygen Therapeutics
PB - John Wiley and Sons
ER -