Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals

Kangcheng Hou; Yi Ding; Ziqi Xu; Yue Wu; Arjun Bhattacharya; Rachel Mester; Gillian M. Belbin; Steve Buyske; David V. Conti; Burcu F. Darst; Myriam Fornage; Chris Gignoux; Xiuqing Guo; Christopher Haiman; Eimear E. Kenny; Michelle Kim; Charles Kooperberg; Leslie Lange; Ani Manichaikul; Kari E. North; Ulrike Peters; Laura J. Rasmussen-Torvik; Stephen S. Rich; Jerome I. Rotter; Heather E. Wheeler; Genevieve L. Wojcik; Ying Zhou; Sriram Sankararaman; Bogdan Pasaniuc

doi:10.1038/s41588-023-01338-6

Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals

Kangcheng Hou
, Yi Ding
, Ziqi Xu
, Yue Wu
, Arjun Bhattacharya
, Rachel Mester
, Gillian M. Belbin
, Steve Buyske
, David V. Conti
, Burcu F. Darst
, Myriam Fornage
, Chris Gignoux
, Xiuqing Guo
, Christopher Haiman
, Eimear E. Kenny
, Michelle Kim
, Charles Kooperberg
, Leslie Lange
, Ani Manichaikul
, Kari E. North

Ulrike Peters, Laura J. Rasmussen-Torvik, Stephen S. Rich, Jerome I. Rotter, Heather E. Wheeler, Genevieve L. Wojcik, Ying Zhou, Sriram Sankararaman, Bogdan Pasaniuc

University of California, Los Angeles
UCLA Samueli School of Engineering
David Geffen School of Medicine at UCLA
Icahn School of Medicine at Mount Sinai
Department of Statistics and Biostatistics
Keck School of Medicine of USC
Fred Hutchinson Cancer Center
The University of Texas Health Science Center
University of Colorado Denver
Lundquist Institute at Harbor-UCLA Medical Center
University of Colorado School of Medicine
University of Virginia School of Medicine
University of North Carolina at Chapel Hill
Northwestern University Feinberg School of Medicine
Loyola University of Chicago
Johns Hopkins University

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	549-558
Number of pages	10
Journal	Nature Genetics
Volume	55
Issue number	4
DOIs	https://doi.org/10.1038/s41588-023-01338-6
State	Published - Apr 2023
Externally published	Yes

ASJC Scopus Subject Areas

Genetics

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10.1038/s41588-023-01338-6

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Hou, K., Ding, Y., Xu, Z., Wu, Y., Bhattacharya, A., Mester, R., Belbin, G. M., Buyske, S., Conti, D. V., Darst, B. F., Fornage, M., Gignoux, C., Guo, X., Haiman, C., Kenny, E. E., Kim, M., Kooperberg, C., Lange, L., Manichaikul, A., ... Pasaniuc, B. (2023). Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals. Nature Genetics, 55(4), 549-558. https://doi.org/10.1038/s41588-023-01338-6

Hou, K, Ding, Y, Xu, Z, Wu, Y, Bhattacharya, A, Mester, R, Belbin, GM, Buyske, S, Conti, DV, Darst, BF, Fornage, M, Gignoux, C, Guo, X, Haiman, C, Kenny, EE, Kim, M, Kooperberg, C, Lange, L, Manichaikul, A, North, KE, Peters, U, Rasmussen-Torvik, LJ, Rich, SS, Rotter, JI, Wheeler, HE, Wojcik, GL, Zhou, Y, Sankararaman, S & Pasaniuc, B 2023, 'Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals', Nature Genetics, vol. 55, no. 4, pp. 549-558. https://doi.org/10.1038/s41588-023-01338-6

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title = "Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals",

author = "Kangcheng Hou and Yi Ding and Ziqi Xu and Yue Wu and Arjun Bhattacharya and Rachel Mester and Belbin, \{Gillian M.\} and Steve Buyske and Conti, \{David V.\} and Darst, \{Burcu F.\} and Myriam Fornage and Chris Gignoux and Xiuqing Guo and Christopher Haiman and Kenny, \{Eimear E.\} and Michelle Kim and Charles Kooperberg and Leslie Lange and Ani Manichaikul and North, \{Kari E.\} and Ulrike Peters and Rasmussen-Torvik, \{Laura J.\} and Rich, \{Stephen S.\} and Rotter, \{Jerome I.\} and Wheeler, \{Heather E.\} and Wojcik, \{Genevieve L.\} and Ying Zhou and Sriram Sankararaman and Bogdan Pasaniuc",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.",

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doi = "10.1038/s41588-023-01338-6",

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AU - Hou, Kangcheng

AU - Ding, Yi

AU - Xu, Ziqi

AU - Wu, Yue

AU - Bhattacharya, Arjun

AU - Mester, Rachel

AU - Belbin, Gillian M.

AU - Buyske, Steve

AU - Conti, David V.

AU - Darst, Burcu F.

AU - Fornage, Myriam

AU - Gignoux, Chris

AU - Guo, Xiuqing

AU - Haiman, Christopher

AU - Kenny, Eimear E.

AU - Kim, Michelle

AU - Kooperberg, Charles

AU - Lange, Leslie

AU - Manichaikul, Ani

AU - North, Kari E.

AU - Peters, Ulrike

AU - Rasmussen-Torvik, Laura J.

AU - Rich, Stephen S.

AU - Rotter, Jerome I.

AU - Wheeler, Heather E.

AU - Wojcik, Genevieve L.

AU - Zhou, Ying

AU - Sankararaman, Sriram

AU - Pasaniuc, Bogdan

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Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals

ASJC Scopus Subject Areas

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