Azaadamantane Benzamide 5-HT4 Agonists: Gastrointestinal Prokinetic SC-54750

Daniel Becker; Daniel L. Flynn; Robert L. Shone; Gary Gullikson

doi:10.1016/j.bmcl.2004.09.005

Azaadamantane Benzamide 5-HT4 Agonists: Gastrointestinal Prokinetic SC-54750

Daniel Becker, Daniel L. Flynn, Robert L. Shone, Gary Gullikson

Department of Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a–d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT4 agonist and 5-HT3 antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.

Original language	American English
Journal	Chemistry: Faculty Publications and Other Works
Volume	14
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2004.09.005
State	Published - Nov 15 2004

Keywords

gastrointestinal prokinetic

Disciplines

Chemistry

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title = "Azaadamantane Benzamide 5-HT4 Agonists: Gastrointestinal Prokinetic SC-54750",

abstract = " Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a–d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT4 agonist and 5-HT3 antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.",

keywords = "gastrointestinal prokinetic",

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AU - Becker, Daniel

AU - Flynn, Daniel L.

AU - Shone, Robert L.

AU - Gullikson, Gary

PY - 2004/11/15

Y1 - 2004/11/15

N2 - Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a–d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT4 agonist and 5-HT3 antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.

AB - Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a–d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT4 agonist and 5-HT3 antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.

KW - gastrointestinal prokinetic

UR - https://ecommons.luc.edu/chemistry_facpubs/22

U2 - 10.1016/j.bmcl.2004.09.005

DO - 10.1016/j.bmcl.2004.09.005

M3 - Article

VL - 14

JO - Chemistry: Faculty Publications and Other Works

JF - Chemistry: Faculty Publications and Other Works

IS - 22

ER -

Azaadamantane Benzamide 5-HT4 Agonists: Gastrointestinal Prokinetic SC-54750

Abstract

Keywords

Disciplines

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