Asymmetric α‐Hydroxy Ketone Synthesis by Direct Ketone Oxidation Using a Bimetallic Palladium(II) Complex.

Othman A. Hamed; Arab El-Qisairi; Hanan Qaseer; Emad M. Hamed; Patrick M. Henry; Daniel Becker

doi:10.1016/j.tetlet.2012.03.066

Asymmetric α‐Hydroxy Ketone Synthesis by Direct Ketone Oxidation Using a Bimetallic Palladium(II) Complex.

Othman A. Hamed
, Arab El-Qisairi
, Hanan Qaseer
, Emad M. Hamed
, Patrick M. Henry
, Daniel Becker

Department of Chemistry and Biochemistry

An-Njaha National University
Mu'tah University
University of Guelph
Loyola University Chicago

Research output: Contribution to journal › Article › peer-review

Abstract

The oxidation of ketones by a chiral bimetallic palladium(II) complex in the presence of CuCl2 in THF–water solvents gave an enantioselective synthesis of α-hydroxyketones in catalytic oxidation utilizing an atmosphere of oxygen. The ee’s ranged from 61% to 92%. The reaction was accelerated by addition of strong acid that presumably increases the rate of enolization.

Original language	American English
Journal	ChemInform
Volume	43
Issue number	36
DOIs	https://doi.org/10.1016/j.tetlet.2012.03.066 https://doi.org/10.1002/CHIN.201236054
State	Published - Sep 4 2012

Keywords

ketone
oxidation
bimetallic
palladium(II) complex

Disciplines

Polymer Chemistry

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10.1016/j.tetlet.2012.03.066License: Unspecified
10.1002/CHIN.201236054License: Unspecified

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title = "Asymmetric α‐Hydroxy Ketone Synthesis by Direct Ketone Oxidation Using a Bimetallic Palladium(II) Complex.",

abstract = " The oxidation of ketones by a chiral bimetallic palladium(II) complex in the presence of CuCl2 in THF–water solvents gave an enantioselective synthesis of α-hydroxyketones in catalytic oxidation utilizing an atmosphere of oxygen. The ee{\textquoteright}s ranged from 61\% to 92\%. The reaction was accelerated by addition of strong acid that presumably increases the rate of enolization.",

keywords = "ketone, oxidation, bimetallic, palladium(II) complex",

author = "Hamed, \{Othman A.\} and Arab El-Qisairi and Hanan Qaseer and Hamed, \{Emad M.\} and Henry, \{Patrick M.\} and Daniel Becker",

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language = "American English",

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T1 - Asymmetric α‐Hydroxy Ketone Synthesis by Direct Ketone Oxidation Using a Bimetallic Palladium(II) Complex.

AU - Hamed, Othman A.

AU - El-Qisairi, Arab

AU - Qaseer, Hanan

AU - Hamed, Emad M.

AU - Henry, Patrick M.

AU - Becker, Daniel

PY - 2012/9/4

Y1 - 2012/9/4

N2 - The oxidation of ketones by a chiral bimetallic palladium(II) complex in the presence of CuCl2 in THF–water solvents gave an enantioselective synthesis of α-hydroxyketones in catalytic oxidation utilizing an atmosphere of oxygen. The ee’s ranged from 61% to 92%. The reaction was accelerated by addition of strong acid that presumably increases the rate of enolization.

AB - The oxidation of ketones by a chiral bimetallic palladium(II) complex in the presence of CuCl2 in THF–water solvents gave an enantioselective synthesis of α-hydroxyketones in catalytic oxidation utilizing an atmosphere of oxygen. The ee’s ranged from 61% to 92%. The reaction was accelerated by addition of strong acid that presumably increases the rate of enolization.

KW - ketone

KW - oxidation

KW - bimetallic

KW - palladium(II) complex

UR - http://onlinelibrary.wiley.com/doi/10.1002/chin.201236054/abstract

U2 - 10.1016/j.tetlet.2012.03.066

DO - 10.1016/j.tetlet.2012.03.066

M3 - Article

VL - 43

JO - ChemInform

JF - ChemInform

IS - 36

ER -

Asymmetric α‐Hydroxy Ketone Synthesis by Direct Ketone Oxidation Using a Bimetallic Palladium(II) Complex.

Abstract

Keywords

Disciplines

Access to Document

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