Asymmetric α‐Hydroxy Ketone Synthesis by Direct Ketone Oxidation Using a Bimetallic Palladium(II) Complex.

Othman A. Hamed, Arab El-Qisairi, Hanan Qaseer, Emad M. Hamed, Patrick M. Henry, Daniel Becker

Research output: Contribution to journalArticlepeer-review

Abstract

The oxidation of ketones by a chiral bimetallic palladium(II) complex in the presence of CuCl2 in THF–water solvents gave an enantioselective synthesis of α-hydroxyketones in catalytic oxidation utilizing an atmosphere of oxygen. The ee’s ranged from 61% to 92%. The reaction was accelerated by addition of strong acid that presumably increases the rate of enolization.

Original languageAmerican English
JournalChemInform
Volume43
Issue number36
DOIs
StatePublished - Sep 4 2012

Keywords

  • ketone
  • oxidation
  • bimetallic
  • palladium(II) complex

Disciplines

  • Polymer Chemistry

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