Personal profile
About
My lab is broadly interested in neural circuit development and how disease or injury affects circuit structure and function. Changes in auditory circuits often underlie hearing disorders, which are among the most common human sensory defects. In addition to its clinical relevance, the auditory system has developed highly specialized cell types and synapses in precise tonotopic circuits to transmit sound information quickly and accurately, making it an ideal system to study neural circuit development. Moreover, auditory sensitivity and perception can be assessed by well-established physiological tests, allowing us to correlate cellular or molecular perturbations to behavioral changes. My lab will use mouse genetics, genomics, imaging and physiological approaches to study how auditory circuits assemble, with an emphasis on identifying the cellular and molecular mechanisms that underlie the development of structurally and functionally unique auditory synapses.
Disciplines
- Biology
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Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons
Bastille, I., Lee, L., Moncada-Reid, C., Yu, W. M., Sitko, A., Yung, A., Zamani, M., Christophersen, N., Maroofian, R., Galehdari, H., Babai, N., Vona, B., Moser, T. & Goodrich, L., Jun 24 2025, In: Cell Reports. 44, 6, 115796.Research output: Contribution to journal › Article › peer-review
Open Access -
Critical role of hepsin/TMPRSS1 in hearing and tectorial membrane morphogenesis: Insights from transgenic mouse models
Yang, T. H., Hsu, Y. C., Yeh, P., Hung, C. J., Tsai, Y. F., Fang, M. C., Yen, A. C. C., Chen, L. F., Pan, J. Y., Wu, C. C., Liu, T. C., Chung, F. L., Yu, W. M. & Lin, S. W., Nov 2024, In: Hearing Research. 453, 109134.Research output: Contribution to journal › Article › peer-review
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Eph and ephrin signaling in the development of the central auditory system
Krasewicz, J. & Yu, W. M., Jan 2023, In: Developmental Dynamics. 252, 1, p. 10-26 17 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Accelerating Peripheral Nerve Regeneration Using Electrical Stimulation of Selected Power Spectral Densities
Yu, W.-M., McCullen, M. & Chen, V.C.-F., Apr 1 2022, In: History: Faculty Publications and Other Works. 17, 4Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem
Hoshino, N., Altarshan, Y., Alzein, A., Fernando, A. M., Nguyen, H. T., Majewski, E. F., Chen, V. C. F., Rochlin, M. W. & Yu, W. M., Nov 2021, In: Journal of Comparative Neurology. 529, 16, p. 3633-3654 22 p.Research output: Contribution to journal › Article › peer-review
Open Access