Personal profile
About
Dr. Grella is an Assistant Professor, Department of Psychology, Loyola University Chicago. Her research is focused on the mechanisms by which memories change across time and how they are updated to incorporate new information. Memories are stored in the brain as cellular ensembles activated during learning and then reactivated during retrieval. However, these ensembles are inherently malleable. She is specifically interested in this malleability. Memory malleability, and the ability to incorporate new information and update environmental representations accordingly is a critical component of behavioral flexibility in learning and memory. She is investigating the involvement of noradrenergic and dopaminergic projections to the hippocampus in assigning new networks to mediate encoding that reflects environmental change.
Disciplines
- Psychology
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Contextual memory engrams, and the neuromodulatory influence of the locus coeruleus
Grella, S. L. & Donaldson, T. N., 2024, In: Frontiers in Molecular Neuroscience. 17, 1342622.Research output: Contribution to journal › Review article › peer-review
Open Access -
Hippocampal cells segregate positive and negative engrams
Shpokayte, M., McKissick, O., Guan, X., Yuan, B., Rahsepar, B., Fernandez, F. R., Ruesch, E., Grella, S. L., White, J. A., Liu, X. S. & Ramirez, S., Dec 2022, In: Communications Biology. 5, 1, 1009.Research output: Contribution to journal › Article › peer-review
Open Access -
Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse
Zaki, Y., Mau, W., Cincotta, C., Monasterio, A., Odom, E., Doucette, E., Grella, S. L., Merfeld, E., Shpokayte, M. & Ramirez, S., Oct 2022, In: Neuropsychopharmacology. 47, 11, p. 1992-2001 10 p.Research output: Contribution to journal › Article › peer-review
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Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear
Grella, S., Fortin, A. H., Ruesch, E., Bladon, J. H., Reynolds, L. F., Gross, A., Shpokayte, M., Cincotta, C., Zaki, Y. & Ramirez, S., 2022, In: Nature Communications. 13Research output: Contribution to journal › Article › peer-review
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Chronic activation of fear engrams induces extinction-like behavior in ethanol-exposed mice
Cincotta, C., Murawski, N. J., Grella, S. L., McKissick, O., Doucette, E. & Ramirez, S., Jan 2021, In: Hippocampus. 31, 1, p. 3-10 8 p.Research output: Contribution to journal › Article › peer-review
Open Access