Research output per year
Research output per year
Personal profile
About
The interest of our lab centers on the developmental stages of Plasmodium within the Anopheles mosquito. For the parasite the mosquito serves two purposes: it provides a) the environment for the completions of sexual development and reproduction and b) transport to the next human host. Yet, the mosquito is not a mere inert flying syringe and represents a serious challenge for the parasite. The environment in the insect is dramatically different from the human blood. In addition to be part of a digesting blood meal the parasite also has to cope with the innate immune response of the mosquito and an expanding bacterial flora – at the same time. Plasmodium therefore has to reorganize its cell biology in order to survive, mate, develop, and move within the mosquito to ultimately facilitate transmission to the next human host. One major adaptive change is the switch from an intracellular life style in the human blood to an extracellular life style in the mosquito vector. This step has the consequence that Plasmodium is now directly exposed to its rather hostile environment which requires the parasite, in form of an ookinete to actively move through and escape the blood meal. It then produces thousands of sporozoites which invade the salivary glands of the insect. From here they will be injected into the next human host.
Disciplines
- Biology
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The evolutionarily conserved PhLP3 is essential for sperm development in Drosophila melanogaster
Petit, C., Kojak, E., Webster, S., Marra, M., Sweeney, B., Chaikin, C., Jemc, J. C. & Kanzok, S. M., Oct 2024, In: PLoS ONE. 19, 10, e0306676.Research output: Contribution to journal › Article › peer-review
Open Access -
The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites
Gupta, Y., Goicoechea, S., Pearce, C. M., Mathur, R., Romero, J. G., Kwofie, S. K., Weyenberg, M. C., Daravath, B., Sharma, N., Poonam, Akala, H. M., Kanzok, S. M., Durvasula, R., Rathi, B. & Kempaiah, P., Jan 2022, In: Medicinal Research Reviews. 42, 1, p. 56-82 27 p.Research output: Contribution to journal › Review article › peer-review
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The Multistage Antimalarial Compound Calxinin Perturbates P. falciparum Ca2+ Homeostasis by Targeting a Unique Ion Channel
Gupta, Y., Sharma, N., Singh, S., Romero, J. G., Rajendran, V., Mogire, R. M., Kashif, M., Beach, J., Jeske, W., Poonam, Ogutu, B. R., Kanzok, S. M., Akala, H. M., Legac, J., Rosenthal, P. J., Rademacher, D. J., Durvasula, R., Singh, A. P., Rathi, B. & Kempaiah, P., Jul 2022, In: Pharmaceutics. 14, 7, 1371.Research output: Contribution to journal › Article › peer-review
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Ribosomal/Nucleolar Stress Induction Regulates Tert-Butyl Hydroperoxide (tBHP) Mediated Oxidative Stress in Anopheles Gambiae Midguts
Tarimo, B. B., Hritzo, B. A., Chun Hin Law, H., Tao, D., Pastrana-Mena, R., Kanzok, S. M., Buza, J. J. & Dinglasan, R. R., Mar 29 2019, In: History: Faculty Publications and Other Works. 12Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Characterization of a Protozoan Phosducin-like Protein-3 (PhLP-3) Reveals Conserved Redox Activity
Kooistra, R. L., David, R., Ruiz, A. C., Powers, S. W., Haselton, K. J., Kiernan, K., Blagborough, A. M., Solamen, L., Olsen, K. W., Putonti, C. & Kanzok, S. M., Dec 31 2018, In: Bioinformatics Faculty Publications. 13, 12Research output: Contribution to journal › Article › peer-review
Open AccessFile