Personal profile
Research Interests
- Genome-wide analyses of the past few years have revealed that a substantial portion of the genetic control of complex traits is exerted through the regulation of gene expression. Much of the genetic variation associated with complex traits falls outside the protein coding regions of genes. Mechanistic understanding of how this variation contributes to phenotype is lacking, but gene regulation is thought to play a major role. We develop and apply methods that fully harness gene regulation within complex trait association and prediction studies.
Disciplines
- Biology
- Computer Sciences
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BDNF/BDNF-AS Gene Polymorphisms Modulate Treatment Response and Remission in Bipolar Disorder: A Randomized Clinical Trial
Shkundin, A., Wheeler, H. E., Sinacore, J. & Halaris, A., Feb 2025, In: Journal of Personalized Medicine. 15, 2, 62.Research output: Contribution to journal › Article › peer-review
Open Access -
A deep catalogue of protein-coding variation in 983,578 individuals
Senior Partnerships and Business Operations, Business Operations and Administrative Coordinators, RGC-ME Cohort Partners, Accelerated Cures, African Descent and Glaucoma Evaluation Study (ADAGES) III, Age-related macular degeneration in the Amish, Albert Einstein College of Medicine, Amish Connectome Project, Amish Research Clinic, The Australia and New Zealand MS Genetics Consortium, Center for Non-Communicable Diseases (CNCD), Cincinnati Children’s Hospital, Columbia University, Dallas Heart Study, Diabetic Retinopathy Clinical Research (DRCR) Retina Network, Duke University, Flinders University of South Australia, Indiana Biobank, Indiana University School of Medicine & Kaiser Permanente & 26 others, , Jul 18 2024, In: Nature. 631, 8021, p. 583-592 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Brain-derived neurotrophic factor and stress perception
Shkundin, A., Wheeler, H. E., Sinacore, J. & Halaris, A., Nov 1 2024, In: Personalized Medicine in Psychiatry. 47-48, 100139.Research output: Contribution to journal › Article › peer-review
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Comparison of GWAS results between de novo tinnitus and cancer treatment-related tinnitus suggests distinctive roles for genetic risk factors
Shahbazi, M., Wheeler, H. E., Armstrong, G. T., Frisina, R. D., Travis, L. B. & Dolan, M. E., Dec 2024, In: Scientific Reports. 14, 1, 27952.Research output: Contribution to journal › Article › peer-review
Open Access -
Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals
Hou, K., Ding, Y., Xu, Z., Wu, Y., Bhattacharya, A., Mester, R., Belbin, G. M., Buyske, S., Conti, D. V., Darst, B. F., Fornage, M., Gignoux, C., Guo, X., Haiman, C., Kenny, E. E., Kim, M., Kooperberg, C., Lange, L., Manichaikul, A. & North, K. E. & 9 others, , Apr 2023, In: Nature Genetics. 55, 4, p. 549-558 10 p.Research output: Contribution to journal › Article › peer-review