Research output per year
Research output per year
Personal profile
About
Lithium salts are used in the treatment of bipolar disorder but the mechanism of action is poorly understood. We focus on two Mg2+-dependent protein systems, G-proteins and GSK-3β, which are key components of signal transduction pathways believed to malfunction in this mental illness. Our approach incorporates a battery of biophysical methods, including fluorescence and circular dichroism spectroscopy, isothermal titration calorimetry, and nuclear magnetic resonance and electron paramagnetic resonance. Using this methodology, we probe the Li+ and Mg2+ binding and competition properties, and the folding of these proteins.
Disciplines
- Biochemistry
- Chemistry
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Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education.
Jelenkovic, A., Jelenkovic, A., Sund, R., Sund, R., Yokoyama, Y., Latvala, A., Sugawara, M., Tanaka, M., Matsumoto, S., Freitas, D. L., Maia, J. A., Knafo-Noam, A., Mankuta, D., Abramson, L., Ji, F., Ning, F., Pang, Z., Rebato, E., Saudino, K. J. & Cutler, T. L. & 29 others, , May 14 2020, In: Scientific Reports. 10, 1Research output: Contribution to journal › Article › peer-review
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Genetics of somatotype and physical fitness in children and adolescents.
Silventoinen, K., Maia, J., Jelenkovic, A., Jelenkovic, A., Pereira, S., Gouveia, É., Gouveia, É., Antunes, A., Thomis, M., Lefevre, J., Kaprio, J., Freitas, D., Freitas, D. & Freitas, D., Jul 7 2020, In: American Journal of Health Behavior.Research output: Contribution to journal › Article › peer-review
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Muscle Mass and Muscle Strength Relationships to Balance: The Role of Age and Physical Activity
Gouveia, É. R., Ihle, A., Gouveia, B. R., Kliegel, M., Marques, A. & Freitas, D. L., Apr 24 2020, In: Journal of Aging and Physical Activity. 28, 2Research output: Contribution to journal › Article › peer-review
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Are there gross motor coordination spurts during mid-childhood?
Santos, M. A. M. D., Baxter‐Jones, A., Reyes, A. C., Freitas, D., Freitas, D., Henrique, R. S., Chaves, R. N., Bustamante, A., Bustamante, A., Tani, G., Katzmarzyk, P. T. & Maia, J., May 7 2019, In: American Journal of Health Behavior. 31, 4Research output: Contribution to journal › Article › peer-review
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Balance and mobility relationships in older adults: A representative population-based cross-sectional study in Madeira, Portugal.
Gouveia, É. R., Gouveia, É. R., Gouveia, É. R., Gouveia, B. R., Ihle, A., Kliegel, M., Marques, A., Marques, A., Freitas, D. L., Freitas, D. L. & Freitas, D. L., Jan 1 2019, In: Archives of Gerontology and Geriatrics. 80Research output: Contribution to journal › Article › peer-review