Research output per year
Research output per year
Personal profile
About
Our research is focused on the design and synthesis of metalloenzyme inhibitors and also of serine protease and serine hydrolase inhibitors with antibiotic properties. In addition, we are interested in the synthesis and conformational dynamics of supramolecular scaffolds related to cyclotriveratrylene (CTV) with applications in host-guest chemistry. Other active research areas involve synthetic methodology including cascade reactions and metal-catalyzed functionalization reactions.
Related documents
Disciplines
- Carbohydrates
- Heterocyclic Compounds
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Macromolecular Substances
- Organic Chemicals
- Medicinal and Pharmaceutical Chemistry
- Pharmaceutics and Drug Design
- Medicinal-Pharmaceutical Chemistry
- Organic Chemistry
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Bioisosteric replacement of pyridoxal-5′-phosphate to pyridoxal-5′-tetrazole targeting Bacillus subtilis GabR
Kaley, N. E., Liveris, Z. J., Moore, M., Reidl, C. T., Wawrzak, Z., Becker, D. P. & Liu, D., Jan 2025, In: Protein Science. 34, 1, e70014.Research output: Contribution to journal › Article › peer-review
Open Access -
Synthesis of Pyrazole-Based Inhibitors of the Bacterial Enzyme N-Succinyl-l,l-2,6-Diaminopimelic Acid Desuccinylase (DapE) as Potential Antibiotics
DiPuma, T., Kelley, E. H., Thabthimthong, T., Bland, A., Konczak, K., Torma, K. J., Mohammad, T. S. H., Olsen, K. W. & Becker, D. P., Jan 2025, In: International Journal of Molecular Sciences. 26, 1, 22.Research output: Contribution to journal › Article › peer-review
Open Access -
Corrigendum: Nα -acetyl-L-ornithine deacetylase from Escherichia coli and a ninhydrin-based assay to enable inhibitor identification(Front. Chem., (2024), 12, (1415644), 10.3389/fchem.2024.1415644)
Kelley, E. H., Osipiuk, J., Korbas, M., Endres, M., Bland, A., Ehrman, V., Joachimiak, A., Olsen, K. W. & Becker, D. P., 2024, In: Frontiers in Chemistry. 12, 1465797.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Cyclobutanone Inhibitors of Diaminopimelate Desuccinylase (DapE) as Potential New Antibiotics
Habeeb Mohammad, T. S., Kelley, E. H., Reidl, C. T., Konczak, K., Beulke, M., Javier, J., Olsen, K. W. & Becker, D. P., Jan 2024, In: International Journal of Molecular Sciences. 25, 2, 1339.Research output: Contribution to journal › Article › peer-review
Open Access -
N α-acetyl-L-ornithine deacetylase from Escherichia coli and a ninhydrin-based assay to enable inhibitor identification
Kelley, E. H., Osipiuk, J., Korbas, M., Endres, M., Bland, A., Ehrman, V., Joachimiak, A., Olsen, K. W. & Becker, D. P., 2024, In: Frontiers in Chemistry. 12, 1415644.Research output: Contribution to journal › Article › peer-review
Open Access